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Archives of Clinical Microbiology
ISSN: 1989-8436
Virology and Infectious Diseases 2019
EuroSciCon Conference on
Virology and Infectious Diseases
B
uniyavirales
order is one of the largest groups of RNA viruses, including more than 350 members distributed among
ten families according to the latest International Committee on Taxonomy of Viruses (ICTV) report. Some of them
can cause disease in humans, including highly pathogenic Crimean-Congo hemorrhagic fever virus (CCHFV) in the
Nairoviridae
family; the Rift Valley fever virus (RVFV), the severe fever with thrombocytopenia syndrome virus (SFTSV)
in the
Phenuiviridae
family; Lacrosse virus and Oropouche virus in the
Peribunyaviridae
family and several hantaviruses
such as Hantaan virus, Sin Nombre virus, Andes virus in the
Hantaviridae
family. Only vaccines for HTNV and SEOV have
been developed in Asia. And no specific drugs are available against these contagious Bunyaviruses. The glycoproteins
(Gn and Gc) on the Bunyaviruses play an important role in particle entry into the target cells. They are also the major
antigens which arise neutralizing antibodies in human body against the infection. This research focuses on the structural
and functional studies of the envelope proteins of RVFV and SFTSV and fished the neutralizing antibodies from the
RVFV infected patients’ PBMCs using the recombinant glycoproteins and then explored the neutralizing mechanisms
based on the antigen-antibody complex structures. These studies provide potential specific drugs against RVFV and
also provide the detailed information of epitope of the antigen, thereby paving way on the vaccine development.
wuy@biols.ac.cnBunyavirus: A group of ancient, but newly defined
virus
Yan Wu
Beijing Institutes of Life Science-Chinese Academy of Sciences, China
Arch Clin Microbiol 2019, Volume:10
DOI: 10.4172/1989-8436-C1-018