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May 24-25, 2018
London, UK
Vascular Surgery 2018
3
rd
Edition of World Congress & Exhibition on
Vascular Surgery
Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
Introduction:
A dedicated ex vivo computer controlled circulatory
bioengineering reactor was designed and constructed to monitor
the real time vascular tissue response under various physiological
conditions.
Methods:
We designed and build dedicated artificial circulatory
model (ACM) for computational projection of vessel structure
under different flow conditions. Next, we analyzed flow through
iliac arteries and silicon tubes supplied with the homemade fluid
that mimic blood. Using ACM we analyzed mechanical behavior
of vessels such as change of diameter and wall displacement.
Accuracy of data collected with ACM was verified with medical
datagatheredfrompatientsbeforeanoperationandreconstructed
with 2D-speckle-tracking-technique (2DSTT).
Results:
The analysis of spatial configuration for silicon tubes
indicated approximately 57% lower change of diameter compared
to the iliac arteries. Meanwhile we observed approximately 2.3-
fold decrease in wall displacement for the silicon tubes compared
to the iliac arteries. Moreover, there were no significant changes
between experimental results and medical data.
Conclusions:
The approach presented in the manuscript may
become a useful tool to introduce different types and spatial
configurations of vessels for different hemodynamic conditions.
By utilizing an ex vivo perfusion system in which ejection volume
and frequency of pulsation can be varied independently, we have
shown different mechanical response of tissue vascular grafts
and silicon tubes.
Recent Publications
1. Polanczyk A, Piechota Polanczyk A and Stefanczyk L
(2017) A new approach for the pre-clinical optimization
of a spatial configuration of bifurcated endovascular
prosthesis placed in abdominal aortic aneurysms. PLoS
One doi: 10.1371/journal.pone.0182717.
2. Polanczyk A, Podyma M, Trebinski L, Chrzastek J,
Zbicinski I and Stefanczyk L (2016) A novel attempt to
standardize results of CFD simulations basing on spatial
configuration of aortic stent-grafts. PLoS One doi:
10.1371/journal.pone.0153332.
3. Polanczyk A, Podyma M, Stefanczyk L, Szubert W and
Zbicinski I (2015) A 3D model of thrombus formation in
a stent-graft after implantation in the abdominal aorta. J
Biomech. 48:425-431.
4. JUrbina,JASotelo,DSpringmuller,CMontalba,KLetelier,
C Tejos, et al. (2016) Realistic aortic phantom to study
hemodynamics using MRI and cardiac catheterization
in normal and aortic coarctation conditions. Journal of
Magnetic Resonance Imaging: JMRI 44:683-97.
5. F Prandi, M Piola, M Soncini, C Colussi, Y D’Alessandra,
E Penza, et al. (2015) Adventitial vessel growth and
progenitor cells activation in an ex vivo culture system
mimicking human saphenous vein wall strain after
coronary artery bypass grafting. PloS One 10:e0117409
Biography
Andrzej Polanczyk is a Researcher and a TeamLeader at the Lodz University
of Technology (Poland). He earned a PhD in Medical Engineering in 2013.
He participated in scientific grants in which he build the installation to simu-
late the blood flow through the abdominal section of the aorta. Recently he
received a grant funded by the National Centre for Research and Develop-
ment. His research areas comprise biomedical, chemical and, environmen-
tal engineering.
andrzej.polanczyk@gmail.comEstimation of hemodynamics in human and artificial vessels
with artificial circulatory model
Andrzej Polanczyk
1, 2
, Aleksandra Piechota Polanczyk
3
, Martin Funovics
1
,
Christoph Domenig
1
, Josif Nanobashvili
1
, Christoph Neumayer
1
and
Ihor Huk
1
1
Medical University of Vienna, Austria
2
Lodz University of Technology, Poland
3
Jagiellonian University, Poland
Andrzej Polanczyk et al., J Vasc Endovasc Therapy 2018, Volume 3
DOI: 10.21767/2573-4482-C1-003