polymer-science-2017-scientifictracks-abstracts

4 / 16

Page 28
Notes:
conferenceseries .com
Polymer Sciences | ISSN: 2471-9935
October 02-03, 2017 Chicago, USA
3rd International Conference on
Polymer Science and Engineering
Design and development of bilayer gastroretentive tablet containing metformin HCl and glipizide for the
treatment of type II diabetes
Girish N Patel1, Hitesh R. Patel1 and Madhabhai M. Patel2
1Ganpat University, India
2Shree Swaminarayan college of pharmacy, Gujarat
The aim of the present research work is to develop and optimize a bilayer antidiabetic floating matrix tablet containing Metformin
HCI (MET) as sustain release in one layer, using different grades of hydroxy propyl methyl cellulose (HPMC) by direct compression
method, and glipizide as immediate release from the remaining layer. Immediate action of glipizide will be helpful to control excess
sugar, which will be maintained by metformin action later on. Thus, the developed single tablet will be sufficient instead of three to
four tablets of both drugs per day, and it will also increase patient compliance and therapeutic efficacy. The formulations of immediate
release layer were prepared by using various super disintegrants i.e. crossprovidone, sodium starch glycolate, and croscarmellose
sodium by direct compression technique. 32 full factorial design was used to optimize sustain release formulations of Metformin HCl.
The ratio of polymer blend (X1) and content of gas generating agents blend (X2) were chosen as independent variables. The tablets
were evaluated for in-vitro dissolution profile, in-vitro buoyancy studies, comparison of dissolution profiles, kinetic modeling and
drug release mechanism. Different super disintegrants were used to prepared immediate release tablets of GPZ. Among these SSG
(5%) give good disintegration and the GPZ was completely released within 1 hr. Among the different grades of HPMC investigated,
significant difference in the resulting MET release profiles from the SR layer of tablets was found. This indicated that the viscosity of
the polymer affects the drug release rate when the drug is water-soluble and the dose is high. The results conclude that bilayer gastro
retentive tablet of Metformin HCl and Glipizide shows desirable release profile, good floating, and sustained effect in stomach. There
is a further scope to conduct the in-vivo studies by using various experimental animal models and correlate the in-vitro- in-vivo
correlation.
Biography
Dr. Girish N Patel is a Ph.D., M. Pharm and he completed his Ph.D from Hemchandracharya North Gujarat University, patan, Gujarat, India. His area of interest mostly lies
in the field of Polymer Technology.
Girish N Patel et al., Polym Sci, 3:3
DOI: 10.4172/2471-9935-C1-002