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7
t h
E u r o p e a n C o n g r e s s o n
Obesity and
Eating Disorder
Obesity 2018
Journal of Obesity & Eating Disorders
ISSN 2471-8203
A p r i l 1 2 - 1 3 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Page 27
B
ariatric surgery is now advocated as a treatment option for type 2 diabetes.
The pathophysiology of improved glycaemic control after these procedures
is not fully elucidated. Bile acids have traditionally been considered mediators
of lipid absorption and cholesterol metabolism. However, in recent years bile
acids have been identified as metabolic molecules which play a significant part
in glucose metabolism amongst others. The metabolic effects are mediated by
activating the nuclear receptor, farnesoid X receptor (FXR) and the G protein-
coupled membrane receptor (TGR5) which may in part attribute to the long
term remission of type 2 diabetes. This session will provide an overview of the
relationship between bile acids and incretin hormones, laboratory analysis of
bile acids as well as explore how altered bile acid metabolism after bariatric
surgery can improve glycaemic control.
Biography
Royce P Vincent is a Consultant Chemical Pathologist at King’s
College Hospital NHS Foundation Trust and an Honorary Senior
Lecturer at King’s College London, UK. He is the Clinical Lead
for Biochemistry and Parenteral Nutrition services. He obtained
his MD (Res) at Imperial College London. His research interests
are in Obesity, Endocrinology and Clinical Nutrition. He has pub-
lished over 45 original research and review articles and is serv-
ing as an International Editorial Board Member for
Translational
Metabolic Syndrome Research
.
royce.vincent@nhs.netAltered bile acid metabolism after bariatric surgery and glycaemic
control
Royce P Vincent
King’s College Hospital NHS Foundation Trust, London, UK
Royce P Vincent, J Obes Eat Disord 2018, Volume: 4
DOI: 10.21767/2471-8203-C1-008