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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 39
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
H
umoral immunodeficiencies are the commonest category of primary
immunodeficiency disease and are characterized by variable degrees
of recurrent infection, malignancy, allergy, and autoimmunity, ranging from
almost absence of all serum immunoglobulin classes and also B cells to
selective antibody deficiency and normal serum immunoglobulin. The 2017
international union of immunodeficiency societies (IUIS) classification
differentiates between nine subgroups. Stratifying the patients based on
clinical and blood biomarkers is needed to improve patients’ care. Retrospective
data analysis was done for 48 cases (different immunodeficiency disorders)
followed in adult allergy and immunology unit, Hamad Medical Corporation
over the last ten years. 27 cases with humoral immunodeficiency analyzed
for IUIS classification, the inflammatory markers, the age of maturation at
presentation, and associated micronutrients levels. Vitamin D was low in
most of the cases. CRP was not statistically significant, but the mean and
median is observationally higher in patients with bronchiectasis. CRP mean
in bronchiectasis, other complications (arthritis, malignancy, and allergy) and
no complications cases are 58±63.2, 9.3±6.12 and 5 and median= 21 (3.3-
167), 6 (5-19) and 5 respectively (P=0.075). Age of presentation to health
service is not an indicator of the presence of multiple comorbidity or severe
outcome. Patients presented with pediatric age group have more incidence of
bronchiectasis. Gender and smoking are not associated with increased rate of
complications in this cohort (P>0.05). The current IUIS classification is limited
regarding the continuity of care, despite being fundamental in the diagnosis
and classifying the diseases. Long-term continuous evaluation and monitoring
are needed in the care of patients with primary immunodeficiency for any
evolving complications, and the guidelines in this area are scanty. Meaningful
stratification may lead to better understanding of the etiology of the diseases,
as well as help tailor effective therapy.
Biography
Al-Nesf MA has completed her MD from Sultan Qaboos
University, Sultanate of Oman in 1999 and Arab Board of
Medical Specialization in 2005 in Medicine. She finished
speciality training in Pulmonary Medicine and in the Allergy
and Clinical Immunology fellowships from 2005-2009. She is
the Head of Allergy and Immunology Section, Hamad Medical
Corporation, Qatar since 2016. Currently, she is advancing
her academic career by studying the degree of Cellular and
Molecular Medicine (MSc) (R) in the Faculty of Biomedical
Science at the University of Bristol, UK. She has published more
than six papers in reputed journals and multiple abstracts
.
Mariamali@hamad.qaStratification of patients with primary immunodeficiency
diseases: relevance to etiology and therapy
Al-Nesf MA
1
, Morgan D
2
, Chandra P
3
and Mohamed-Ali V
4
1
Hamad Medical Corporation, Qatar
2
University of Bristol, United Kingdom
3
Hamad Medical Corporation, Qatar
4
Anti-doping Lab Qatar, Qatar
Al-Nesf MA et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-002