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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 36
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
A
ccording to the traditional models for peripheral T-cell tolerance, T-cells
and regulatory T-cells (Tregs) have to be bound to MHC on the same
antigen presenting cell (dendritic cell), whereby the Tregs downregulate the
non-Tregs. Here, I will discuss new models/hypotheses where Tregs regulate
non-Tregs directly in an antigen specific way, and I will further discuss how
extracellular microvesicles may play a role in keeping the Tregs active. In
modern immunotherapy, we use different biological drugs to combat cancer
and autoimmune diseases. Unfortunately, these treatments attack the immune
system in a very wide way and therefore they have some potential serious side
effects. A nice goal for “immunologists” could be to develop antigen-specific
modulators for cancer and autoimmune diseases. New models of the immune
system will lead us in that direction.
Biography
Kim Varming is a Medical Specialist in Clinical Immunology.
Since 2003 he has been theMedical Director for the department
of Clinical Immunology at Aalborg University Hospital. He is a
Board Member in The Danish Society for Clinical Immunology
and in the Organization of Transfusion Centers in Denmark. He
has published more than 60 papers in Peer Reviewed journals.
His main research areas are General Immunology, Extracellular
Vesicles and Cellular cancer-immunotherapy
.
kv@rn.dkNew hypotheses for the maintenance of peripheral T-cell tolerance
Kim Varming
Aalborg University Hospital, Denmark
Kim Varming, Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-002