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Chemistry Education 2018 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Page 19
August 27-28, 2018
Zurich, Switzerland
8th Edition of International Conference on
Chemistry Education
and Research
T opical formulations are commercially avaiable in several
dosage forms such as creams, gels, ointments, foam etc.
Optimization of drug content in the dosage form is a critical
quality attribue to balance the therapeutic activity of the drug
molecule and localized toxicity. This study was therefore
designed to screen various formulations for in vitro release of
hydroquinone as a model drug from topical bases including
diiferent non inonic and anionic gel based formulation in
addition to the emulsion based cream formulation with and
without different penetration enhancers and compared to
cmmercially available product. Vertical Franz diffusion cell
based on principle of equilibrium microdialysis, cellulose
membrane and donated human skin membrane were utilized
to evaluate release form different semisolid formulations. To
estimate the drug release patterns, in vitro release data were
treated to determine physicochemical parameters, such as
steady state flux, diffusion coefficient, permeability coefficient
and partition coefficient. The results led to development
of a formulation that provided higher release of drug at
half the concentration of the marketed product. It was also
demonstrated that in case of topical formulations, not the
concentration of the drug in the formulation but the nature
of the base and layer of formulation in contact with the skin
surface presents the drug release.
Biography
Vaishnavi Parikh has completed her PhD in Pharmaceutics from Philadel-
phia College of Pharmacy, University of Sciences. She has more than eight
years of experience working as a Formulation Scientist in the pharmaceu-
tical industry and currently works as a Manager of product development at
Genus Lifesciences Inc. She has published several papers in reputed jour-
nals; presented at several international conferences; has been serving as a
reviewer on six reputed journals and also an editor for the journal, Insight-
Automatic Control.
Efficacy of topical drug delivery and significance of semisolid
bases
Vaishnavi Parikh1, 2
1Long Island University, USA
2Genus Lifesciences, USA
Vaishnavi Parikh, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C5-014