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E u r o S c i C o n C o n f e r e n c e o n
Chemistry
2018
Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
F e b r u a r y 1 9 - 2 0 , 2 0 1 8
P a r i s , F r a n c e
Page 52
P
olymeric nanoparticles (NPs) are of high interest for numerous applications
inmedicine, including targeteddrug toaconsiderablepotential for treatment
of many human diseases. The important technological advantages of NPs
usage as drug carriers are their high stability, high carrier capacity, feasibility
of encapsulation of both hydrophilic or hydrophobic substances, as well as a
high variety of possible administration routes. Various degradable and non-
degradable polymers of both natural and synthetic origin have been used for
NPs construction. One of the most promising for the design of NPs are amino
acid-based biodegradable polymers - poly (ester amide) s (PEAs) which will
be cleared from the body after the fulfilment of their function. The used PEAs
are composed of naturally occurring and non-toxic building blocks such as
α-amino acids, fatty diols and dicarboxylic acids. In our previous research we
have performed a systematic study for the preparation of biodegradable NPs by
cost-effective nanoprecipitation method using PEAs. The present work deals
with the fabrication of the surface modified biodegradable NPs that includes
the PEGylation (coating with polyethylene glycol, PEG) and imparting positive
charge to the particulates. The PEGylation of NPs is important for improving
their biocompatibility whereas positive surface charge (zeta-potential) is
necessary for enhancing permeability through the biological barriers. The PEA
composed of L-leucine, 1,6-hexanediol and sebacic acid (8L6) was used as
a basic polymer for fabricating the NPs, and the arginine based cationic PEA
composed of L-arginine, 1,6-hexanediol and sebacic acid (8R6) was employed
for imparting them the positive charge. An originally designed comb-like PEA,
containing lateral PEG-2000 chains along with 8L6 anchoring fragments, was
used as a PEGylating surfactant. It has been established that depending on
the fabrication conditions a size and zeta-potential of the NPs could be tuned
within 78÷161 nm and +7.5÷+23.2 mV, respectively.
Biography
Tem Kantaria has his expertise in the preparation and charac-
terization of nanoparticles based on amino acid based biode-
gradable poly(ester urea)s. Currently he is pursuing his PhD de-
gree and engaged in the preparation, modification and charac-
terization of new biodegradable nano and microparticles on the
bases of amino acid-based ester polymers (poly(ester amide)s
and poly(ester urea)s).
tkant2015@agruni.edu.geNanoparticles for medical applications made of biodegradable
amino acid-based polymers: preparation and modification
Tem Kantaria, Teng Kantaria, S Kobauri, D Tugushi and R
Katsarava
Institute of Chemistry and Molecular Engineering - Agricultural University of Georgia, Georgia
Tem Kantaria, J Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C1-003