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E u r o S c i C o n C o n f e r e n c e o n
Chemistry
2018
Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
F e b r u a r y 1 9 - 2 0 , 2 0 1 8
P a r i s , F r a n c e
Page 50
I
n 1900, Betti was the first to prepare 1-(a-aminobenzyl)-2-naphthol by simple
condensation of 2-naphthol with benzaldehyde and ammonia. Aminoalkyl
naphthols (Betti bases) and amidoalkyl naphthols with 1,3-amino-oxygenated
Functional group are considered as a class of biologically natural active
products and potent drugs, which include many nucleosides, antibiotics,
and human immunodeficiency virus protease inhibitors, such as lopinavir
and ritonavir. Several Lewis and Brønsted acids such as SnCl
4
5H
2
O, polymer-
supported sulfonic acid, ionic liquids, nano-sulfated zirconia, [HMIM]C(CN)3,
ZrO(OTf)
2
, Bi(NO
3
)
3
.5H
2
O have been applied to catalyze this transformation.
However these catalytic systems suffer from one of the following limitation
such as the use of expensive and toxic reagents/catalysts, limited availability
of reagent, hygroscopicity as well as instability of the reagents, use of
strong protic media, harsh reaction condition, long reaction time, low yields,
tedious work up procedure. In this work efficient, mild and eco-friendly
procedure of 1-aminoalkyl-2-phenol/betti base from one pot three component
condensations of Aldehyde, Phenol and Morpholine in presence of sulfated
polyborate catalyst, under solvent-free condition at 100°C (Scheme 1). The
catalyst has been prepared and used as a Bronsted as well as Lewis acid
catalyst for the reaction. The catalyst was prepared by dehydration of boric acid
followed by sulfonation and characterized by different analytical techniques
such as potentiometric analysis, FTIR, XRD, SEM-EDAX. The major advantages
of the present method are short reaction time, high yields, Aqueous work-
up procedure, Low cost, stable, reusable catalyst and solvent-free reaction
conditions are the key features of the present protocol.
Biography
Manisha S Patil has completed her MPharm from North Maha-
rashtra University and PhD Studies from Institute of Chemical
Technology. She has recently published 3 papers in reputed
journals in short time.
msp214@gmail.comSulfated polyborate catalysed – solvent free and recyclable
catalyst for efficient synthesis of betti base
Manisha S Patil, Chetan Khatri and Ganesh U Chaturbhuj
Institute of Chemical Technology, Mumbai, India
Manisha S Patil, J Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C1-003