8 / 14
Page 26
Nano Research & Applications
ISSN 2471-9838
September 11-12, 2017 Amsterdam, Netherlands
20
th
International Conference on
Advanced Nanotechnology
Notes:
Advanced Nano 2017
Selective detection of glucose, cholesterol and urea
with metal-oxide nanostructures based field-effect
transistors array biosensors
N
anotechnology revolution has led to the
nanofabrication of sensor devices for rapid and
specific identification of chemical/biological species.
However, the development of multiplexed nanoscale
biosensor for simultaneousdetectionof different analytes
still remains a major challenge at the nanotechnology
frontier. It is well recognized that diabetes mellitus is
a metabolic disorder resulting in an abnormal blood
glucose level and activation of several metabolic
pathways related to inflammation and apoptosis events.
Heart disease and stroke due to excess cholesterol
in blood is the leading cause of death and disability,
and kidney failure due to excess urea is caused by
urea cycle disorders. We have developed metal-oxide
nanostructures based, integrated field-effect transistors
(FETs) array biosensor with simultaneously immobilizing
GOx, ChOx and Ur enzymes on three separated
FET arrays. In this lecture, we report a novel straight
forward approach for simultaneous and highly selective
detection of multi-alanytes (i.e., glucose, cholesterol
and urea) with the FETs array biosensor without
interference in each sensor response. Compared to
analytically measured data, performance of the FETs
array biosensor is found to be highly reliable for rapid
detection of multi-analytes in mice blood, serum and
blood samples of diabetic dogs. The development of an
integrated, low-cost FETs array biosensor will produce
quick detection under critical patient conditions, early
identification of disease/disorder, and also have an
enormous impact on the future generations.
Biography
Yoon-Bong Hahn is Fellow of Korea Academy of Science and Technology,
Director of BK21 Center for future energy materials and devices, Director of
National Leading Research Lab for hybrid green energy, and Head of School of
Semiconductor and Chemical Engineering, Chonbuk National University (CBNU).
He joined CBNU in 1991, prior to which he worked for LG Metals Research Center
from 1988 to 1991 after he received his PhD in Metallurgical Engineering from
University of Utah in 1988. His main research interest is the synthesis of metal and
metal oxide nanostructures and their applications for optoelectronic devices and
chemical and biological sensors, resulting in over 270 peer-reviewed SCI papers
and 14 patents. He co-authored six books including
Metal Oxide Nanostructures
and Their Applications
(five volume sets) published in March 2010 by American
Scientific Publishers. He also has 11 registered and nine applied patents.
ybhahn@chonbuk.ac.krYoon-Bong Hahn
Chonbuk National University, South Korea
Yoon-Bong Hahn, Nano Res Appl 2017, 3:3
DOI: 10.21767/2471-9838-C1-001