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Nano Research & Applications
ISSN 2471-9838
September 11-12, 2017 Amsterdam, Netherlands
20 th International Conference on
Advanced Nanotechnology
Notes:
Advanced Nano 2017
Nanofiber Technology for 3D Nano-Biointerface
Fabrication and Cellular Engineering
The significance of the overall fibrillar and porous
nanoscale topography of the extracellular matrix
(ECM) in promoting essential cellular processes has
led to consideration of biomaterials with nanofibrous
features. Of the many methods for fabricating
fibers with micrometer and nanometer diameters,
electrospinning is simplest, most straightforward and
cost-effective. Fibers are produced by forcing a polymer
melt or solution through a spinneret in the presence of
a high electric field. This approach becomes intriguingly
powerful when remarkable morphological features
such as very large surface area to volume ratio and
porosity are combined with unique chemical, physical,
or mechanical functionalisation by adding desired
components with ease and control. Our current research
focuses on exploring new possibilities to fabricate
three-dimensional Nano-biointerfaces that recapitulate
the in vivo environment. The developed biocompatible,
therapeutics-incorporated nanofibers synergise the
nanostructural induction and the bioactives signalling
to affect cellular behaviours, such as gene knockdown,
cell adhesion and migration, proliferation and stem
cell differentiation. The biomimetic nanofibers that are
responsive to different stimuli, such as temperature, pH,
light, and electric/magnetic field were also developed
for on-demand therapeutic delivery and intervention.
Biography
Dr Chen has completed her PhD in 2008 fromAarhus University and is currently an
Assistant Professor at Department of Engineering, Interdisciplinary Nanoscience
Center (iNANO), Aarhus University in Denmark, and visiting assistant professor at
Stanford University School of Medicine. She leads the research group of Nanofiber
Technology and Cellular Engineering, and has published more than 50 peer-
reviewed papers in reputed journals.
Menglin Chen
Aarhus University, Denmark
Menglin Chen, Nano Res Appl 2017, 3:3
DOI: 10.21767/2471-9838-C1-001