advanced-materials-nano-engineering-2018-tracks

Page 50

Volume 4

December 10-12, 2018

Rome, Italy

Nano Research & Applications

ISSN: 2471-9838

Advanced Materials 2018

Nano Engineering 2018

JOINT EVENT

International Conference on

Advanced Materials

and Simulation

Edition of International Conference on

Nano Engineering &

Technology

anotopological cues can be exploited to investigate

the molecular interactions between biomolecules and

nanomaterials. However, studies highlighting the synergistic

effect of nanostructure shape, size and geometry inmodulating

biosensing parameters are non-existent. To explore this,

poly(3,4- ethylenedioxythiophene) bearing hydroxyl functional

group in the side chain having R or S chirality with dot and

tube morphology were synthesized and the synergistic effect

of polymer chirality and nano-topography morphology in

controlling the biomolecule-polymeric nano-surface binding

affinity were studied. Accordingly, the design of a bio-

sensing nanosurface for enhanced sensitivity and signal/

noise ratio is proposed. Chiral polymers were synthesized via

electrochemical polymerization using cyclic voltammetry or

chrono-amperometry techniques. The formation of polymers

was confirmed through UV/ Visible spectrophotometry

and Fourier Transform Infrared spectroscopy (FTIR) while

the chirality was confirmed through circular dichroism

(CD). Hydrophobicity or hydrophilicity of the polymeric

nanostructures was analysed by measuring their respective

water contact angles. Electrochemical polymerization

temperature was varied to obtain either nanodot or nanotube

morphology while the potential was changed to modulate the

nano-topography size. The nanostructure morphology was

confirmed using Scanning Electron Microscopy (SEM). Fetal

Bovine Serum (FBS) was used as a model protein and Quartz

crystal microbalance (QCM) was used to analyse the binding

affinity of biomolecules to different chiral nanostructures.

Water contact angle measurement confirmed that, nanotubes

showed a greater hydrophilicity as compared to dots

irrespective of the chirality. Finally, QCM data revealed a 15

and 20Hz difference in the binding affinities of R and S-PEDOT

when the nanostructure morphologies were same and a 12

and 17Hz difference in the binding affinities when the polymer

chirality were same, confirming that polymer chirality and

nanostructure morphology play a crucial role in determining

the binding affinity of biomolecules to nanostructures.

These results collectively indicated the existence of a fine

balance between nanostructure and analyte size, which has

to be optimized to achieve maximal bio sensing response.

Applications in the field of bio-materials and biomedical

engineering are expected.

Biography

Jayakrishnan A.J is expertized in designing of organic molecules for vari-

ous applications. He is currently working on the design, synthesis and elec-

trochemical fabrication of conducting polymer nanostructures, especially

functionalized poly (3,4- ethylenedioxythiophene) for various material as

well as biological applications. He is pursuing his doctoral studies in Insti-

tute of Chemistry at Academia Sinica, Taiwan with the prestigious Taiwan

International Graduate Program (TIGP) scholarship.

jayakrishnanaj@gate.sinica.edu.tw

Design and Fabrication of Functionalized, Chiral

Poly(3,4-ethylenedioxythiophene) (PEDOT)

Nanostructures for Biosensing Applications

Jayakrishnan A. J

1,2,3

Udesh Dhawan

,Tharwat Mansoure

and

Hsiao-hua Yu

1,2

Smart Organic Material Laboratory, Institute of Chemistry, Academia Sinica, Taipei, Taiwan

Taiwan International Graduate Program (TIGP), Sustainable Chemical Science & Technology

(SCST),

3Dept.of

Applied Chemistry, National Chiao Tung University (NCTU), Hsinchu, Taiwan

Jayakrishnan A. J et al., Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C7-027