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Pharmacognosy 2018 American Journal of Ethnomedicine
ISSN: 2348-9502 Page 69
April 16-17, 2018
Amsterdam, Netherlands
6th Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Phytochemical and pharmacological study of Dianthus
hyssopifolius L., a medicinal plant from the “Sierra del Caurel”
Lucía Bada, Dolores Viña and Elías Quezada
Universidade de Santiago de Compostela, Spain
In recent years, natural resources have regained great importance
in the development and research of new pharmacological
agents. “Sierra del Caurel” is a natural spot located in the
heart of Galicia (Spain). It is presented as a potent reservoir of
bioactive secondary metabolites. Dianthus hyssopifolius L. is an
herbaceous plant belonging to the Caryophyllaceae family. It has
been used as a medicinal plant for decades by the inhabitants
of the “Sierra del Caurel” because of its antirrheumatic and
anticatarrhal properties. However, to date, few phytochemical
and pharmacological data have been reported on species of
the genus Dianthus. Therefore, Dianthus hyssopifolius L. has
been selected to study its composition and therapeutic activity.
To obtain the secondary metabolites, extraction with organic
solvents was first carried out. The whole plant was macerated
fresh in methanol at room temperature. The crude extract was
resolved in methanol:water (3:1) and extracted with hexane.
The polar phase was evaporated under reduced pressure to
methanol: water (1:5) after extraction with dicloromethane.
After evaporation of the solvent, three oil extracts were obtained:
hexane, dichloromethane and methanol. The methanol extract
was solubilized in hot ethanol to yield a yellow precipitate.
Sephadex LH-20 and silica gel column chromatography as well
as HPLC were used in order to fractionate the precipitate and to
purify the obtained compounds. Using one- and two-dimensional
NMR experiments and mass spectrometry, two flavonoids have
been identified: a glycoside derived from quercetin and another
from kaempferol. According to the bibliography review, study
of antibacterial, anticancer, antifungal, anti-inflammatory, and
antioxidant properties for the different extracts are currently in
progress.
Recent Publications
1. Aliyazicioglu R, Demir S, Badem M, Sener S O, Korkmaz
N, et al. (2017) Antioxidant, antigenotoxic, antimicrobial
activities and phytochemical analysis of Dianthus
carmelitarum. Records of Natural Products 11:3.
2. Chandra S and Rawat D S (2015) Medicinal plants of
the family Caryophyllaceae: a review of ethno-medicinal
uses and pharmacological properties. Integrative
Medicine Research 4(3):123–131.
3. Blanco E, Macıa M J, Morales R (1999) Medicinal and
veterinary plants of El Caurel (Galicia, Northwest Spain).
Journal of Ethnopharmacology 65(2):113–124
Biography
Lucía Bada is a Graduate in Pharmacy from the Universidade de Santiago
de Compostela (Spain), 2015. She has a Master’s Degree in Research and
Development of New Drugs. Her passion lies in natural products, especially
medicinal plants. She is interested in medicinal and chemical properties of
phyto-preparations and phytotherapy researches in order to assess their sci-
entific value, promote their pharmacological valorization and stimulate sus-
tainable drug development with a high socioeconomic potential that would
enhance the welfare of communities.
Lucía Bada et al., Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006