15 / 50
Pharmacognosy 2018
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 75
April 16-17, 2018
Amsterdam, Netherlands
6
th
Edition of International Conference on
Pharmacognosy and
Medicinal Plants
Perspectives on dermatological and cosmeceutical properties
of compound K
En Hyung Kim
Dankook University, South Korea
G
insenosides are representative pharmaceutical compounds
found in various forms in Panax ginseng, a traditional
medicinal plant. There have been many reports describing the
biological activities, including anti-inflammatory, anti-tumor, and
anti-dementia effects, of several ginsenosides. The biological
actions of these ginsenosides have been closely related to their
biotransformations by intestinal microbiome. They are converted
to their metabolites Rg2, Rg3, compound K, and others by human
intestinal microflora following ingestion. The main functional
component detected in mammalian blood or organs after oral
administration of ginseng or ginsenosides is compound K.
Compound K has been reported to exhibit diverse biological
functions, including antitumor, antidiabetic, antiallergic, and
anti-inflammatory effects
in vitro
and
in vivo
. Recently, antiaging
effects of ginsenosides in human skin have been reported from
clinical trial and
in vitro
model data. Ginsenosides have hence
been proposed as promising natural cosmeceutical agents. We
reviewed the biotransformation and delivery of compound K.
Also biological effects of ginsenosides, especially compound K,
on skin health and its potential use as cosmeceutical agents was
studied.
Recent Publications
1. Kim E H (2017) Pruritic urticarial papules and plaques
of pregnancy occurring postpartum treated with
intramuscular injection of autologous whole blood. Case
Rep Dermatol. 9(1):151–156.
2. Kim E H (2017) A case of facial partial unilateral
lentiginosis treated with low-fluence 1,064 nm
Q-switched neodymium-doped yttrium aluminum garnet
laser. Case Rep Dermatol. 9(2):30–34.
3. Kim E H, Park M J, Park S and Lee E S (2015) Increased
expression of the NLRP3 inflammasome components
in patients with Behçet’s disease. J Inflamm (Lond).
2(12):41.
4. Nam S W, Ko S Y, Lee Y K, Shin S M and Kim E H (2014)
The incidence of birthmarks in Korean newborn infants.
Neonatal Med. 21(3):151–157.
5. Lee J Y, Park J Y, Kim E H, Tak M J and Lee E S
(2012) Simultaneous involvement of nervous and
gastrointestinal systems in Behçet’s disease. Ann
Dermatol. 24(2):225.
Biography
En Hyung Kim finished her residency in Dermatology at Ajou University
Hospital and is currently the Director of Department of Dermatology at Cheil
General Hospital and Women’s Healthcare Center. As a Scientist, she is in-
terested in Skin Physiology and Inflammatory Mechanisms. As a Clinician,
shemakes effort to find new innovative ways to treat her patients effectively
and safely.
imehk77@gmail.comEn Hyung Kim, Am J Ethnomed 2018, Volume 5
DOI: 10.21767/2348-9502-C1-006