organic-chemistry-2018-scientifictracks

8 / 13

Organic Chemistry 2018 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Page 24
August 16-17, 2018
Dublin, Ireland
6th Edition of International
Conference and Exhibition on
Organic Chemistry
Aminofluorene and its derivatives have proved to be one
of the most widely studied candidates among in cancer
research. They have also found its applications as efficient
ds-RNA fluorescent probe. Most common approach for the
synthesis of aminofluorene is based on the hydrogenation
of corresponding nitro/nitrile fluorenes as starting material.
However, to the best of our knowledge, decyanization reaction
has never been used to obtain 1-hetarylsubstituted-3-
aminofluorene. Furthermore, the desired compounds are also
difficult to afford through conventional protocols such Suzuki
coupling, functionalizing of bromide substituted fluorene etc.
The decyanization reaction provides not only the removal of
cyano groups from the structure but also unprecedented side
products because of harsh reaction conditions, such as the
alkylated 1-hetaryl-3-aminofluorene derivatives. In this study,
on a facile protocol to obtain 1-hetaryl-3-aminofluorene and
its side products besides the catalytic reduction of various
corresponding nitro-substituted fluorene compounds which
are difficult to synthesize by other methods. Furthermore, a
proposed mechanism has been outlined for the achieved novel
type of aminofluorene products by means of XRD, Mass and
NMR spectroscopy.
Recent Publications
1. Yalcin Ergin et al. (2017) Novel fluorene/fluorenone DNA
and RNA binders as efficient non-toxic ds-RNA selective
fluorescent probes. Tetrahedron. 74(5):535-543.
2. B Sahoo et al. (2017) Biomass-derived catalysts for
selective hydrogenation of nitroarenes. ChemSusChem.
10(15):3035-3039.
3. Formenti Dario et al. (2017) Co-based heterogeneous
catalysts from well-defined α-diimine complexes:
discussing the role of nitrogen. Journal of Catalysis.
351:79-89.
Biography
Ergin Yalcin currently works at the Graduate School of Natural and Applied
Sciences of Gazi University. His research interest focuses on the synthesis
of novel ligands which may have interaction with biomolecules ( G-Quadru-
plex DNA, ds-DNA, RNA etc.) that have a challenging task to identify biologi-
cal important processes. He is also interested in: Ligand- DNA/RNA interac-
tion, supramolecular chemistry and sensing of molecules.
The synthesis of 3-amino-1-hetarylfluorene derivatives and
their unprecedented side products
Ergin Yalcin
Gazi University, Turkey
Ergin Yalcin, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-011