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Organic Chemistry 2018 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Page 33
August 16-17, 2018
Dublin, Ireland
6th Edition of International
Conference and Exhibition on
Organic Chemistry
Greater than 80% of drugs and biologically active natural
products are nitrogen- or oxygen-based, and many of
these exist as nitrogen or oxygen heterocycles. While many
such drugs and natural products are also chiral, relatively
few contain chiral nitrogen/oxygen heterocycles, a limitation
that is due in large part to a lack of effective and broadly
applicable methods for their preparation. However, as drug
development moves away from the use of unsaturated (flat),
structurally simple achiral compounds and seeks out more
stereochemically sophisticated chiral compounds having
higher degrees of saturation, the need for methods for the
synthesis of chiral nitrogen/oxygen heterocycles has become
increasingly important. We have developed stereocontrolled
synthetic approaches to a wide range of saturated and partially
saturated chiral nitrogen/oxygen heterocycles through the use
of two newly developed azoalkene-based moieties, the details
of which are described herein.
Recent Publications
1. Uteuliyev M M, Nguyen T T and Coltart D M (2015)
Diastereoselective addition of Grignard reagents to
α-epoxy N-sulfonyl hydrazones. Nature Chem. 7:1024-
1027.
2. Hatcher J M, Kohler MC and Coltart DM (2011) Catalytic
asymmetric addition of thiols to nitrosoalkenes leading
to chiral non-racemic α-sulfenyl ketones. Org. Lett.
13(15):3810-3813.
3. Hatcher J M and Coltart D M (2010) Copper-(I) catalyzed
addition of Grignard reagents to in situ-derived N-sulfonyl
azoalkenes: an alkylation procedure applicable to the
formation of up to three contiguous quaternary centers.
J. Am. Chem. Soc. 132(13):4546-4547
Biography
Don MColtart obtained his Master’s Degree from the University of Manitoba
(Canada) under the supervision of Professor James L Charlton and then
joined the research group of Professor Derrick L J Clive at the University
of Alberta where he obtained his PhD. His Postdoctoral work was conduct-
ed at the Memorial Sloan-Kettering Cancer Center as Natural Sciences and
Engineeering Research Council, Alberta Heritage Foundation for Medical
Research, and CRI Scholar under the supervision of Professor Samuel J
Danishefsky. He began his independent career at Duke University in 2004
and moved to the University of Houston in 2012 where he is an Associate
Professor. His research interests include: the development of methods for
asymmetric carbon–carbon bond formation, the application of those meth-
ods to the total synthesis of structurally complex biologically active natural
products, and the study of those compounds in biological systems.
Stereocontrolled synthesis of chiral N- and O-heterocycles
Don M Coltart
University of Houston, USA
Don M Coltart, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-011