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Organic Chemistry 2018 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Page 20
August 16-17, 2018
Dublin, Ireland
6th Edition of International
Conference and Exhibition on
Organic Chemistry
Oxidative cross-dehydrogenative coupling methodology lies
in the modern trend of organic chemistry. It eliminates
necessity for installation of additional functional groups
and affords direct coupling in one stage (via selective C-H
activation) with limited amount of wastes, high atom- and
step- economy. Oxidative cross-dehydrogenative C-C coupling
were studied in detail; the C-N, C-P, and C-O cross-coupling
reactions are less well developed. It is difficult to achieve
high selectivity in the cross-dehydrogenative C-O coupling
because the starting compounds are prone to side oxidation
and fragmentation reactions giving, for example, alcohols and
carbonyl compounds. This gives rise to a problem of searching
for oxidizing agents and reaction conditions suitable for the
cross-coupling of different types of substrates. We discovered
oxidative cross C-O coupling of 1,3-dicarbonyl compounds,
their heteroanalogs and heterocycles with peroxides, oximes
and hydroxyamides. The best result obtained with the use of
the widely available copper, iron, manganese or lanthanide
salts as catalysts or oxidants.
Recent Publications
1. A O Terentev et al. (2014) Iminoxyl radical based
strategy for intermolecular C-O bond formation: cross
dehydrogenative coupling of 1,3 dicarbonyl compounds
with oximes. Adv. Synth. Catal. 356(10):2266-2280.
2. I B Krylov, V A Vil’ and A O Terent’ev (2015) Cross-
dehydrogenative coupling for the intermolecular C-O
bond formation. Beilstein J. Org. Chem. 11(2015):92-
146.
3. I B Krylov et al. (2017) Selective cross-dehydrogenative
C–O coupling of N-hydroxy compounds with
pyrazolones: introduction of the diacetyliminoxyl radical
into the practice of organic synthesis Org. Chem. Front.
4(10):1947-1957.
Biography
Alexander O Terentev pursued PhD Degree (2000); DSc Degree (2009). He
worked as a Professor at the DMendeleev University of Chemical Technolo-
gy of Russia (2011). He became the head of laboratory at N D Zelinsky Insti-
tute of Organic Chemistry of the Russian Academy of Sciences (2014), head
of laboratory in All Russian Research Institute of Phytopathology (2016). He
has published 3 chapters of books, 100 research papers, and 30 patents.
His research interests include: organic chemistry, medicinal and agricultural
chemistry and chemical technology.
Oxidative cross-coupling with C-O bond formation
Alexander O Terentev, Alexander S Budnikov, Stanislav A Paveliev and Oleg V
Bityukov
N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia
Alexander O Terent’ev et al., J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-011