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Organic Chemistry 2018 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Page 46
August 16-17, 2018
Dublin, Ireland
6th Edition of International
Conference and Exhibition on
Organic Chemistry
Pyridine derivatives are an important class of azaheterocycles
found in many natural products, active pharmaceuticals and
functional materials. Whereas pyridine-derived pharmaceuticals
include Atazanavir (Reyataz®) and Imatinib mesylate (Gleevec®),
respectively prescribed for human immunodeficiency virus
(HIV) and chronic myelogenous leukemia. In particular, some
pyridotriazepines derivatives possess diverse bioactivities,
such as analgesic, anti-inflammatory, anticancer, antihelminthic,
fungicide, and antagonistic activity towards several receptor.
In this work, and as part of our ongoing research focusing on
developing synthetic routes to heterocyclic derivatives with
potential biological activities, we herein report a safe, facile, fast,
one-pot reaction and ecofriendly synthesis of a novel substituted
4,8-dioxo-pyrido[1,2-b] [1,2,4] triazepines (3a-l) from epoxides 2.
The new proposed synthetic routes seem to be of interest, since
they have been comparedwith existingmethods. The synthesized
pyridotriazepines are characterized using spectral methods (IR,
1H NMR, 13C NMR and MS), then they were screened at first for
their antioxidant activities using DPPH, FRAP and ABTSmethods.
The results show that the antioxidant properties don’t follow the
same tendency in all assays, due to the nature of the scavenged
radicals and the reaction mechanism. Also, the present study
revealed that the nature of the substituent on the phenyl ring
is crucial for the exhibited antioxidant activities, and that the
increased activities follow systematically the order CH3˃Cl˃H.
Furthermore the synthesized compounds were also evaluated
for their antibacterial activity against four pathogenic bacteria
which are Staphylococcus sp, Escherichia coli sp, Bacillus sp and
Enterobacterium sp.Theantibacterial effectwasdeterminedusing
the Muller-Hinton agar diffusion method for bacterial strains. The
results shows that these compounds have good inhibitory activity
towards the studied pathogenic strains. The minimum inhibitory
concentrations are also determined for the samples that were
displayed the best antibacterial power.
Synthesis and evaluation of antibacterial and antioxidant
activity of new derivative pyrido [1,2-b] [1,2,4] triazepine
derivatives
Houda Serrar
Ibn Tofaïl University, Morocco
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-012