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Organic Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Page 43
August 16-17, 2018
Dublin, Ireland
6
th
Edition of International
Conference and Exhibition on
Organic Chemistry
T
he interest of the chemical community towards “one-pot”
reactions increased rapidly over the past two decades. These
processes, whichalso include tandemreactions, arecharacterized
by a high level of atom and step economy. Tandem reactions are
often used to prepare heterocycles of high biopharmacological
value. To facilitate the reaction design, the utilization of
bifunctional building blocks in tandem reactions has emerged as
an important research area of organic chemistry. However, most
of the bifunctional compounds are not easy to synthesize due
to the difficulty of installing two or more reactive sites into one
molecule. Many 2-substituted benzaldehydes belong to this class
and have been widely used in tandem reactions for the synthesis
of heterocyclic compounds. In this context, even though ketones
are less electrophilic than aldehydes, the investigation of the
reactivity of 2-acylbenzonitriles and related ketones appears to be
of high interest because of the possibility to obtaining derivatives
with tetrasubstituted stereocenters in a single pot process.
Thus, in the present communication, the scope and the great
potentialities of bifunctional aromatic ketones as electrophiles in
asymmetric reactions will be discussed. In addition, a convenient
synthesis of 2-acylbenzonitriles starting from readily available
materials is proposed.
amassa@unisa.itSynthesis of 2-acylbenzonitriles and reactivity in
organocatalytic tandem reaction: easy access to heterocycles
with tetrasubstituted carbon
Antonio Massa
University of Salerno, Italy
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-012