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Organic Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Page 50
August 16-17, 2018
Dublin, Ireland
6
th
Edition of International
Conference and Exhibition on
Organic Chemistry
D
espite tremendous advances accomplished through
developing cheaper and more versatile chemical catalysts
and optimizing the reaction media, the global needs for clean
manufacturing technologies, management of hazardous
chemicals and waste present new research challenges to both
chemistry and biotechnology. Recent advances in biocatalysis,
fueled by either protein engineering or screening, greatly
improved the number of synthetic opportunities from small
chiral polyfunctional molecules to highly complex analogs.
Chiral 1,2-amino alcohols, 1,3-diols and carboxylic acids are the
vital structural components of a large number of biologically
active molecules with potential pharmaceutical relevance
and in chiral auxiliaries. The development of new protocols
utilizing biocatalysts/chemocatalysts for the stereoselective
synthesis of these molecules continue to be of great interest in
organic chemistry. The present work involves the biocatalytic
approaches towards the synthesis of these molecules by panel
of microorganisms bearing lipases/oxidoreductases belonging to
IIIM-Jammu, SMVDU-Katra repositories as well as those procured
from commercial sources. The immobilization of the substrate
on a solid inert support as well as immobilization of enzymes
significantly improved the enantioselectivity factor (E). The effect
of acyl substituents and co-solvents were also studied.
pankajrrl@gmail.comPankaj Gupta
Government Degree College Kathua, India
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-012
Biocatalytic approaches towards enantioselective
synthesis of 1,2-amino alcohols and other useful
precursors of bioactive molecules