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Organic Chemistry 2018 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Page 41
August 16-17, 2018
Dublin, Ireland
6th Edition of International
Conference and Exhibition on
Organic Chemistry
T he development of synthetic approaches that meet the
principles of green chemistry for the synthesis of molecules
biological interests is one of the current quests. Among these
molecules, we have the thioamides. The Willgerodt-Kindler (WK)
reaction is one of the most widely used synthetic methods for
accessing thioamides. The purpose of our work is to study this
reaction in acid heterogeneous catalysis with montmorillonite
K-10 under microwave activation for the synthesis of phenyl
derivatives (morpholino) methanethiones. Our work shows that
the mixture (aldehyde, sulfur, morpholine and K-10) is not only
suitable, but optimizes the reaction. K-10 was easily separated
from the reaction mixture and was recycled at least two times
without any loss of activity. Operational simplicity, short reaction
times, excellent yields and benign environmental conditions are
also the advantages of this protocol, thus respecting the principles
of green chemistry. In summary the synthesis of thiobenzamides
in heterogeneous acid catalysis with the K-10 of the Willgerodt-
Kindler reaction for carbonyl compounds is a simple, efficient
protocol that respects the principles of green chemistry. The
structures of thioamides synthesized were characterized and
confirmed by high-resolution mass spectrometry (HRMS) and
nuclear magnetic resonance (NMR) 1D and 2D (COSY, HSQC,
HMBC).
Green synthesis of thiobenzamide derivatives by Willgerodt
Kindler reactions in acidic catalysis with montmorillonite k-10
Agnimonhan Finagnon Hyacinthe
University of Abomey Calavi, Benin
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-012