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conferenceseries
.com
Volume 3, Issue 3 (Suppl)
J Obes Eat Disord
ISSN: 2471-8203
Obesity Medicine 2017
October 30-31, 2017
October 30-31, 2017 Bangkok, Thailand
15
th
International Conference on
Obesity Medicine
Bipolar disorder: A psychiatric comorbidity in patients with Prader-Willi syndrome, a case series
Katherine Callaghan
1
and Michael Nevid
2
1
Stony Brook University School of Medicine, USA
2
Winthrop University Hospital, USA
Case Presentation:
Here we present 5 cases of pediatric and adolescent patients with PWS who exhibited episodic manic or
hypomanic symptoms indicative of bipolarity. We subsequently discuss the individual treatment regimens of each patient.
Literature Review:
Prader-Willi Syndrome (PWS) is a genetic disorder caused by loss of function on chromosome 15
(q11-q13). Baseline behavioral problems such as preoccupation with food or skin picking can make psychiatric diagnoses
difficult to recognize in this population. Obsessive-compulsive tendencies and aggression are well known psychiatric illnesses
seen in younger PWS populations. Autism spectrum diagnoses have been noted as well. However, little has been reported on
the pediatric and adolescent population regarding bipolarity. In regards to treatment of psychiatric comorbidity, SSRIs have
had efficacy in limiting obsessive compulsive and aggressive symptoms in some patients. For psychotic episodes, atypical
antipsychotics have had some success, as well as lithium for cycloid psychosis in adults. Regardless of diagnosis, psychiatric
comorbidity is an atypical feature of PWS10. When it does occur, individualized treatment should be explored to address these
issues for optimization of patient health.
Clinical Significance:
We have shown that bipolarity can be seen in pediatric and adolescent patients with PWS. The use of
the antipsychotic Ziprasidone in these patients has helped to prevent further manic episodes. Ziprasidone, a weight neutral
atypical, may be a better option than other atypicals when considering hyperphagia in PWS patients.
Biography
Katherine Callaghan is currently a Medical student at Stony Brook University School of Medicine. She has obtained BS from Cornell University and is currently
pursuing her Ph.d in developmental and behavioral pediatrics.
katherine.callaghan@stonybrookmedicine.eduKatherine Callaghan et al., J Obes Eat Disord 2017, 3:3
DOI: 10.21767/2471-8203-C1-006