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conferenceseries
.com
Volume 3, Issue 3 (Suppl)
J Obes Eat Disord
ISSN: 2471-8203
Obesity Medicine 2017
October 30-31, 2017
October 30-31, 2017 Bangkok, Thailand
15
th
International Conference on
Obesity Medicine
Signs of a delayed development of the frontal-thalamic system, which forms part of the brain substrate
of executive functions, are observed more often in children aged 9-10 with obesity than in their lean
counterparts
Gaukhar Datkhabayeva
1
, Akkumis Salkhanova
1
, Maikul Kainarbayeva
2
, Ainur Sadykova
3
, Diana Koibagarova
1
, Shamil Tazhibayev
1
, Toregeldy
Sharmanov
1
and Bakitkul Kilybayeva
1
1
Kazakh Academy of Nutrition, Kazakhstan
2
Asfendiyarov Kazakh National Medical University, Kazakhstan
3
Al-Farabi Kazakh National University, Kazakhstan
O
bese children have reduced indices of certain cognitive functions from the executive domain (EF). RMachinskaya assumed
that the difficulties with attention in children with ADHD originate from immaturity or non-optimal functional state of
the frontal-thalamic system (FTS), which manifests itself as bilaterally-synchronous groups of theta waves in the frontal and/or
central leads (FCTW) in the rest-state EEG. MRT studies have detected structural deviations as well as delayed development,
primarily in the frontal lobes of the brain of obese adolescents. We have analyzed the frequency of FCTW occurrences in the
EEG of 52 children with obesity and 46 matching children with normal weight (NW) and evaluated attention, mental flexibility
(MF) and response inhibition in FCTW and Non-FCTW children with obesity and NW. Among children with obesity, FCTW-
children were more common than among their lean counterparts (60% and 30%, respectively). Towards the end of the letter
cancellation test (LCT), the obese children exhausted their attention. No observable differences were found in the cognitive
outcomes between the Non-FCTW children with obesity and NW, while the FCTW-children with obesity demonstrated
poorer performance in MF and number of viewed letters in the LCT vis-a-vis their lean counterparts. FCTW presence in the
EEG of children with obesity positively correlates with the reaction time in a response inhibition test. In the FCTW-children,
BMI and MF correlate reversely. Thus, children with obesity have an increased probability of a delayed functional development
of FTS. It seems that children with a delayed development (or non-optimal state) of FTS combined with obesity have lower
cognitive outcomes due to the fact that obesity exacerbates delays in the development or non-optimal state of FTS.
Biography
Gaukhar Datkhabayeva completed her Ph.d in Human Physiology and thesis was devoted to EEG-investigation of functional brain state self-regulation. She
has worked at the Kazakh Academy of Nutrition as a Senior Researcher for a number of years and has carried out investigations of food and behavioral factors
contributing to childhood obesity, as well as the influence of obesity on children’s cognitive functions, as part of a program of prevention of pediatric obesity in
school-age children in Kazakhstan. Her research interests are on popularization of healthy nutrition and elaboration of effective strategies for the promotion of
healthy nutrition choices.
gaukhar_da@bk.ruGaukhar Datkhabayeva et al., J Obes Eat Disord 2017, 3:3
DOI: 10.21767/2471-8203-C1-006