nanobiotechnology-2018-scientifictracks

Nanobiotechnology 2018

Page 39

Nano Research & Applications

ISSN: 2471-9838

E u r o S c i C o n C o n f e r e n c e o n

Nanotech & Nanobiotechnology

J u l y 1 2 - 1 3 , 2 0 1 8

P a r i s , F r a n c e

he pulmonary route offers many advantages for drug delivery such as the

high surface area and the close proximity to the blood circulation. The

air-blood barrier of the alveoli in the lungs is around 500 nm thick. Above the

epithelium cells of the alveoli lies a thin aqueous layer with a thickness of 50-

80 nm. A monolayer of phospholipids, natural lipids and few proteins called the

lung surfactant (LS) adsorbs onto this aqueous film. The major phospholipid

classes include phosphatidylcholines and phosphatidylglycerols. One of the

main roles of the LS is to reduce the surface tension experienced in the lungs

during breathing cycles in order to prevent lung collapse. From the perspective

of pulmonary drug delivery, the LS is the first point of interaction for the

drug carriers. With the advancements of nanomedicine, nanoparticles (NPs)

became highly relevant as novel drug delivery systems. In particular, there is

a great scientific interest for the use of biodegradable NPs for the pulmonary

delivery route. The objective of our work is to develop a biomimetic model of

the LS and study the effects upon interaction with NPs. Therefore, we focus on

understanding the mechanism of interaction between biodegradable polymeric

NPs with the biomimetic model of the LS and test whether the stability and

lateral architecture of LS is affected. These measurements are done by using

Langmuir monolayers at the air-water interface and imaged using Brewster

angle microscopy. Results show that the film stability upon compression is not

affected, but there are significant changes in the lateral domain organization of

the LS upon NP addition. This work is significant because it helps understand

the mechanism of NP-LS interaction and will provide an

in-vitro

screening

approach to assess nanotoxicology.

Biophysical studies on the interaction of polymeric

nanoparticles with the lung surfactant

W Daear and E J Prenner

University of Calgary, Canada

W Daear et al., Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C2-011

Biography

W Daear is a PhD Candidate at the University of Calgary. She

has a Bachelor’s degree in Biological Sciences with a minor in

Nanoscience. She currently has 3 publications in peer reviewed

articles (

J. Phys. Chem. B., Colloids Surf. B, and Biochim.

Biophys. Acta, Biomember