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Nanobiotechnology 2018
Page 38
Nano Research & Applications
ISSN: 2471-9838
E u r o S c i C o n C o n f e r e n c e o n
Nanotech & Nanobiotechnology
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
M
ucosal drug delivery is a technique for administration of drugs through
mucous membranes lining the gastrointestinal tract, respiratory tract,
urogenital tract and ocular surface. It has several advantages including
increased residence time at the site of absorption/action, decreased
administration frequency and thus better patient compliance. However, with
conventional mucosal drug delivery these could only be achieved to a certain
degree. Thus, in this study, two strategies have been used to improve the
efficiency of mucosal drug delivery through the preparation of mucoadhesive
and mucus-penetrating nanoparticles. Thiolated silica nanoparticles have
been synthesised using 3-mercaptopropyltrimethoxysilane and functionalised
with either polyethylene glycol (PEG) or poly (2-ethyl-2-oxazoline) (POZ).
The sizes of thiolated, PEGylated and POZylated silica nanoparticles were
53±1, 68±1 and 59±1 nm, respectively. The particle size of both thiolated
and POZylated nanoparticles significantly increased at pH≤2, whereas no
particle size change was observed at pH 2.5-9 for both these two types of
nanoparticles. On the other hand, the size of PEGylated nanoparticles did not
change over the studied pH range (1.5-9). Thiolated nanoparticles were more
mucoadhesive in the rat small intestine than both PEGylated and POZylated
nanoparticles. This may indirectly indicate the mucus-penetrative properties
of both PEGylated and POZylated nanoparticles. Each of these nanoparticles
has potential applications in mucosal drug delivery.
Synthesis of thiolated, PEGylated and POZylated silica
nanoparticles and evaluation of their retention on rat
intestinal mucosa
in vitro
Twana Mohammed M Ways
1
, Wing Man Lau
2
and Vitaliy V
Khutoryanskiy
1
1
University of Reading, UK
2
Newcastle University, UK
Twana Mohammed M Ways et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C2-011
Biography
Twana Mohammed M Ways has completed his MSc from
University of Sulaimani. He is a PhD student at University of
Reading, UK. He has published 1 review paper.
t.m.m.ways@pgr.reading.ac.uk