nanobiotechnology-2018-scientifictracks

Nanobiotechnology 2018

Page 38

Nano Research & Applications

ISSN: 2471-9838

E u r o S c i C o n C o n f e r e n c e o n

Nanotech & Nanobiotechnology

J u l y 1 2 - 1 3 , 2 0 1 8

P a r i s , F r a n c e

ucosal drug delivery is a technique for administration of drugs through

mucous membranes lining the gastrointestinal tract, respiratory tract,

urogenital tract and ocular surface. It has several advantages including

increased residence time at the site of absorption/action, decreased

administration frequency and thus better patient compliance. However, with

conventional mucosal drug delivery these could only be achieved to a certain

degree. Thus, in this study, two strategies have been used to improve the

efficiency of mucosal drug delivery through the preparation of mucoadhesive

and mucus-penetrating nanoparticles. Thiolated silica nanoparticles have

been synthesised using 3-mercaptopropyltrimethoxysilane and functionalised

with either polyethylene glycol (PEG) or poly (2-ethyl-2-oxazoline) (POZ).

The sizes of thiolated, PEGylated and POZylated silica nanoparticles were

53±1, 68±1 and 59±1 nm, respectively. The particle size of both thiolated

and POZylated nanoparticles significantly increased at pH≤2, whereas no

particle size change was observed at pH 2.5-9 for both these two types of

nanoparticles. On the other hand, the size of PEGylated nanoparticles did not

change over the studied pH range (1.5-9). Thiolated nanoparticles were more

mucoadhesive in the rat small intestine than both PEGylated and POZylated

nanoparticles. This may indirectly indicate the mucus-penetrative properties

of both PEGylated and POZylated nanoparticles. Each of these nanoparticles

has potential applications in mucosal drug delivery.

Synthesis of thiolated, PEGylated and POZylated silica

nanoparticles and evaluation of their retention on rat

intestinal mucosa

in vitro

Twana Mohammed M Ways

, Wing Man Lau

and Vitaliy V

Khutoryanskiy

University of Reading, UK

Newcastle University, UK

Twana Mohammed M Ways et al., Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C2-011

Biography

Twana Mohammed M Ways has completed his MSc from

University of Sulaimani. He is a PhD student at University of

Reading, UK. He has published 1 review paper.