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Nanobiotechnology 2018
Page 27
Nano Research & Applications
ISSN: 2471-9838
E u r o S c i C o n C o n f e r e n c e o n
Nanotech & Nanobiotechnology
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
The antibacterial activity of gold nanorod (GNR) suspensions of
different surface functionalities was investigated against standard
strains of Staphylococcus aureus and Propionibacterium acnes, taking into
consideration two commonly overlooked factors: the colloidal stability of
GNR suspensions upon mixing with bacterial growth media and the possible
contribution of impurities/molecules in GNR suspensions to the observed
antibacterial activity. The results demonstrated that cationic polyallylamine
hydrochloride (PAH)-GNR were severely aggregated when exposed to bacterial
growth media compared to other GNR suspensions. In addition, the free
cetyltrimethylammonium bromide (CTAB) present in GNR suspensions is most
likely the origin of the observed antibacterial activity. However, the antibacterial
activity of GNR themselves could not be excluded. Probing these two critical
control studies prevents misinterpretations and artifacts of the antibacterial
activity of nanoparticles. Unfortunately, these practices are usually ignored in
the published studies and may explain the significant conflicting results. In
addition, this study indicates that GNR could be a promising candidate for the
treatment of skin follicular diseases such as acne vulgaris.
Biography
Nouf Nawaf Mahmoud completed her Bsc in Pharmacy (the
University of Jordan), MSc in Clinical Pharmacy (the University
of Jordan) and a PhD in Pharmaceutical Technology (the
University of Jordan) before joining the academic staff at Al-
Zaytoonah University of Jordan. She is an Assistant Professor
of Pharmaceutics at the faculty of Pharmacy and a member
of Quality Assurance committee at the faculty. Her research
focusesontheNanotechnologyand itsbiomedicalapplications,
understanding the nano-bio interface and in particular the gold
nanoparticles-skin interactions and developing advanced
trasdermal delivery nano systems.
Antibacterial activity of gold nanorods against Staphylococcus
aureusand Propionibacterium acnes: misinterpretations and artifacts
Nouf N Mahmoud, Alaaldin M Alkilany, Enam A Khalil and
Amal G Al-Bakri
The University of Jordan, Jordan
Nouf N Mahmoud et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C2-011