nanobiotechnology-2018-scientifictracks

10 / 18

Nanobiotechnology 2018
Page 28
Nano Research & Applications
ISSN: 2471-9838
E u r o S c i C o n C o n f e r e n c e o n
Nanotech & Nanobiotechnology
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
One of the major unsolved problems in pharmaceutical drug development is
the poor water solubility of many active pharmaceutical ingredients (APIs)
and hence reduced bioavailability. One of the preferred strategies to address
this problem was to leverage the increased solubility with decreasing drug
particle size. However, an ideal solution would be to eliminate the problem of
solubility entirely, by reducing the API size to clusters of a fewmolecules, bound
by weak, Vander Waal’s forces that would readily dissociate into molecules,
during enteral or parenteral drug delivery process. In order to have commercial
impact, such molecular clusters should also be produced in sufficiently high
yield. In our research, we have successfully addressed both these challenges.
We report the precipitation of molecular clusters of ibuprofen using a rapid
expansion of super critical solution (RESS) system. Our custom designed
liquid N2 cooled collection process of the molecular clusters embedded in
dry ice, resulted in yields of up to 80% (w/w). Ambient dissolution of the dry
ice in deionized water resulted in a stable dispersion, for up to six months,
as confirmed by DLS and AFM characterizations. DLS measurements showed
that PEI surfactant (Mw ~400,000) produced the smallest particle size of 7 nm,
with a narrow size distribution of ±3 nm. Drop casting of these dispersions
on silicon and sapphire substrates resulted in high quality, liquid like viscous
films as observed by optical microscopy and AFM. XRD and confocal Raman
characterizations confirmed that the molecular clusters retained their
chemical identity of ibuprofen. Besides its scientific importance, this invention
is expected to open up new drug delivery platforms.
Biography
Sudhir Kumar Sharma obtained his Masters’ degree (MSc
Physics and M. Tech-Materials) from Department of Physics,
Barkatullah University Bhopal, India. He received his PhD from
the Indian Institute of Science Bangalore, India. He joined as
Postdoc fellow at Centre for Nano Science and Engineering
(CeNSE), IISc. Bangalore, India. Later he moved to New York
University Abu Dhabi UAE (NYU Abu Dhabi) as a Research
Associate in 2013. Currently, he is working as a Research
Scientist at NYU Abu Dhabi. His publication record includes
more than 30 journals and 60 conference presentations. His
research interest includes implementation of supercritical
technologies for nanoparticle synthesis, smart materials
for micro-sensors and actuators, micro/nano- fabrications,
vacuum science, and thin film technology.
Synthesis of sub-10 nm ibuprofen drug molecular clusters via
RESS processing
Sudhir Kumar Sharma and Ramesh Jagannathan
New York University Abu Dhabi, UAE
Sudhir Kumar Sharma et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C2-011