nanobiotechnology-2018-posters-abstracts

Nanobiotechnology 2018

Page 62

Nano Research & Applications

ISSN: 2471-9838

E u r o S c i C o n C o n f e r e n c e o n

Nanotech & Nanobiotechnology

J u l y 1 2 - 1 3 , 2 0 1 8

P a r i s , F r a n c e

luorescent molecular probes have become a powerful tool in protein research. However, these probes are less suitable

for analysing specifc populations of proteins in their native environment. In this talk I will give an overview of a new class

of fluorescent molecular probes that we have developed in recent years and show how they can be used to detect individual

proteins, protein combinations, as well as binding interactions and dynamic changes that occur on their surfaces. In the second

part of this talk, I will describe a new class of fluorescent molecular sensors that combines the properties of small molecule-

based probes cross-reactive sensor arrays (the so-called chemical nose/tongue. On the one hand, the probe can detect different

protein families by generating unique identifcation patterns, akin to the cross-reactive arrays. On the other hand, its unimolecular

structure and selective binding allows identifying combinations of specifc protein isoforms in complex mixtures and inside living

cells, where macroscopic arrays cannot access.

Pattern-generating fluorescent molecular

probes for chemical biology

Leila Motiei and David Margulies

Weizmann Institute of Science, Israel

Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C2-012