9 / 53
Medchem & Toxicology 2018
Page 53
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Osteocalcin, control the regulation of blood sugar and fat deposition through
synergistic mechanisms, so osteocalcin directs the pancreas’ beta cells to
produce more insulin, at the same time, osteocalcin directs fat cells to release
adiponectin, which improves insulin sensitivity.
Aims of the research:
There was a suggestion to the research that estimates
the concentration of osteocalcin and some antioxidant parameters in control
and diabetic patients (Type I and Type II) and the coefficients between them.
Materials & Methods:
This study included (70) healthy subjects (35 female,
35 male). Also, (75) patients (37 female, 38 male) with diabetes mellitus from
al-waffa center for diabetic patients in Mosul city in Iraq, their ages ranging
between (≤ 15 - ≥ 65) years old.
Results:
The results demonstrated a significant decrease in the concentration
of osteocalcin in serum of type I and type II diabetic patients compared with
control and between type I diabetic patients compared with type II. The results
also showed a significant increase of adiponectin concentration between type
I diabetic patient compared with type II and control , while found a significant
decrease in the concentration of thioredoxin in serum of diabetic patients
(type I) compared with control and diabetic patients (type II), also a significant
increase in the concentration of malondialdehyde (MDA), total lipids, total
cholesterol, triglyceride, Very low density lipoprotein-cholesterol (VLDL-C)and
Low density lipoprotein-cholesterol (LDL-C) in serum of diabetic patients(type
I and II), and a significant decrease in the concentration of glutathione(GSH),
High density lipoprotein-cholesterol (HDL-C), magnesium, and zinc in serum
of diabetic patients (type I and II) compared with control. Correlation
coefficients between osteocalcin and some antioxidant parameters of control
and diabetic patients showed that osteocalcin concentration has a significant
negative correlation with concentration of total cholesterol, triglycerides,
VLDL and LDL-C. While a significant positive correlation with concentration
of thioredoxin, GSH, HDL, and zinc in control and diabetic patients (type I and
II). Also osteocalcin has a significant negative correlation with concentration
of MDA and has a significant positive correlation with concentration of
adiponectin in control and type II diabetic patients.
Conclusion:
these results provide evidence of a major role for osteocalcin in
diabetes mellitus .Also there are correlations between osteocalcin and Some
Antioxidant parameters.
Biography
Thikra A Allwsh has completed her PhD from Mosul University.
She has published more than 30 papers in reputed journals
and has been serving as an Editorial Board Member of repute.
She is serving as Professor at University of Mosul in the field
of biochemistry. She is the head of the of Biochemistry and
then supervised many Doctoral and Master's studies. She
participated in the discussion of a large number of students
of Master's and Doctorate and also participated in many
conferences and seminars in the field of biochemistry as well
as supervision of the projects of undergraduate students.
Allwsh2007@yahoo.comAssociation of osteocalcin with some antioxidant parameters
in diabetes mellitus in Iraq
Thikra A Allwsh and Liqa'a S Abdulla
University of Mosul, Iraq
Thikra A Allwsh, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009