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Medchem & Toxicology 2018
Page 52
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
P
hytochemicals are well known that plant produce these chemicals to
protect themselves but recently many researchers work to isolated,
separation and identification many natural products which are very important
to human. The phytochemical research is an effective approach of the bioactive
and therapeutic assay. Natural products chemistry and research deals with
chemical compounds found in nature that usually has a pharmacological
or biological activity for use in pharmaceutical drug discovery and drug
design. The plant under study is
Plantago lanceolata
(Pl) is grown in the Iraqi
environment profusely and they are widely used in folk medicine. We carried
out the extraction of chemicals of volatile oils from dried plant parts by using
cleavanger apparatus, while other chemical separation have been acquired
continuously by soxhlet, using different organic solvents (petroleum ether,
chloroform, ethanol and also hot ethanol). We also obtained the fractions from
the crude extracts by using column chromatography technique, and extracted
fatty acids from the extracts of petroleum ether and it's parts of each plants
after saponification process, while phenols and organic acids were obtained
from the parts of the crude extracts (chloroform, ethanol, and hot ethanol) after
acid hydrolysis process. The NMR spectroscopy technique was also used for
identification of these isolated compounds from the obtained fractions using
1
HNMR and
13
C-NMR, then we obtained several pure compounds which are
identified as followings; luteolin, pheophytin B, sitosterol, daucosterol, bezoic
acid, coumarin, dihydrocoumarin. The experimental results of antioxidant and
anticancer showed that luteolin compound has antioxidant activity of 72.68%
at 8 µL concentration compared with standard sample which was 80.06% at
the same concentration. On the other hand, the anticancer result of the same
compound was 60% on the normal cells (PNT2a), while its activity on the
cancer cells (A2780) was 80%.
Biography
Muthanna Jasim Mohammed is an Assistant Professor of
Natural Products in University of Mosul, College of Education
for Pure Science, Biology Department. He completed his PhD
in Natural Products at University of Mosul in 2013. He worked
a part of his PhD research in Strathclyde University in Glasgow,
UK. He completed his MSc in Plant Sciences at University of
Mosul in 2000 and BSc in Biology at University of Mosul in 1997.
He have many article publications in natural products isolation
and identification of compounds which used in drug. He has
published more than 20 papers in reputed journals.
mj_mk_73@yahoo.comSepration and identification of many natural products of
Iraqi plant Plantago lanceolata and study of its antioxidant
and anticancer therapy
Muthanna J Mohammed
University of Mosul, Iraq
Muthanna J Mohammed, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009