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Medchem & Toxicology 2018
Page 57
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Context & Aim:
Respiratory depression or delayed and recurrent respiratory arrest is the major complication of methadone (MTD)
toxicity. We aimed to evaluate the efficacy of naltrexone (NTX) in maintaining adequate ventilation and to prevention of delayed
apnea.
Materials & Methods:
In a double blind randomized clinical trail, a total of 60 non-opioid dependent patients with diagnosis of
acute MTD toxicity at a poison center were evaluated. 30 patients in control group received placebo and 30 in intervention group
received 50 mg NTX.
Results:
Apnea or bradypnea (RR: 12/min) was detected in 9.3% and 11 20.4% of patients, respectively. All of these patients were
belongs to patients in control. The incidence of respiratory depression in patients who received NTX significantly was lower than
that did not (p=0.02). Respiratory depression occurred in 59.2% of patients in the placebo and at none of the patients in NTX
group. The hospital stay in patients who received NTX was significantly lower than control group.
Conclusion:
Administration of single 50 mg dose of NTX can prevent delayed or recurrent apnea in acute MTD toxicity, especially
in children
.
aghabikloo.a@iums.ac.ir aghabikloo@yahoo.comOral naltrexone and effective ventilation in
acute methadone overdose
Abbas Aghabiklooei
1
and Hossein Hassanian
2
1
Iran University of Medical Sciences, Iran
2
University of Shahid-beheshti, Iran
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009