medicinal-chemistry-toxicology-2018-posters

Medchem & Toxicology 2018

Page 74

Journal of Organic & Inorganic Chemistry

ISSN: 2472-1123

A n n u a l C o n g r e s s o n

Medicinal Chemistry,

Pharmacology and toxicology

J u l y 3 0 - 3 1 , 2 0 1 8

Am s t e r d a m , N e t h e r l a n d s

ancer has been considered to be very dreadful disease.

Holmskioldia sanguinea

is a large climbing shrub found in the

Himalayas at an altitude of 5,000 ft and preliminary investigation showed the excellent yield of andrographolide and subjected

for the anticancer activity. Protective effect of

Holmskioldia sanguinea

leaf ethanolic extract has been investigated against Ehrlich

ascites carcinoma (EAC) and Dalton’s ascites lymphoma (DAL) in Swiss albino mice and to evaluate the possible mechanism

of action. The enzymatic antioxidant status was studied on tumor bearing mice, which shows the potential of the compound to

possess significant free radical scavenging property and revealed significant tumour regression and prolonged survival time. The

isolated bioactive molecule andrographolide from

Holmskioldia sanguinea

yields (2.5%) when subjected to HPTLC/HPLC analysis.

The cellular defense system constituting the superoxide dismutase, catalyses was enhanced whereby the lipid peroxidation

content was restricted to a larger extent. The

Holmskioldia sanguinea

is a new source of andrographolide and demonstrated the

potency in treatment of cancer.

Protective effect of the standardized extract of

Holmskioldia sanguinea on tumor bearing mice

Mahesh Pal, Tripti Mishra, Ch V Rao and S K Barik

CSIR-National Botanical Research Institute, Rana pratap Marg, Lucknow, Uttar Pradesh, India

J Org Inorg Chem 2018, Volume 4

DOI: 10.21767/2472-1123-C3-009