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Medchem & Toxicology 2018
Page 72
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
U
lcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue that obstructs the normal
function of an organ. No single cause has been found for ulcers. However, it is now clear that ulcer can be caused by an
imbalance between digestive fluids in the stomach and duodenum and by a type of bacteria called
Helicobacter pylori (H. pylori).
Helicobacter pylori
is a Gram-negative, microaerophilic bacterium found in stomach, produce large amounts of urease enzyme
which breaks down the urea present in the stomach to carbon dioxide and ammonia. Hyperactivity of enzyme urease is one of
the major contributors in different pathologic conditions, like urolithiasis, urinary catheter encrustation, pyelonephritis, hepatic
coma, ammonia and hepatic encephalopathy. Hyperactivity of urease brings out considerable economic and environmental
tribulations by releasing abnormally large quantity of ammonia into the atmosphere in the process of urea fertilization. To date,
only acetohydroxamic acid has been clinically used for the treatment of urinary tract infections by urease inhibition. In the current
situation, the increasing resistance of bacterial pathogens to common antibiotics is the alarming situation for researchers
working in this field. Therefore, it is foremost task to develop the novel classes of molecules that specifically target urease as
enzyme inhibitors.
khalid.khan@iccs.eduDiscovery of novel urease inhibitors for
treatment of peptic ulcer
Khalid Mohammed Khan
International Center for Chemical and Biological Sciences (H E J Research Institute of Chemistry),
University of Karachi, Karachi, Pakistan
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009