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Medchem & Toxicology 2018
Page 66
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
A
number of contaminants of emerging concern with hormone-like activities have been shown to disrupt normal reproductionby
affecting components of brain-pituitary and gonadal axis. Our field studies demonstrated the presence of a number of
pollutants in rivers located in Southern Alberta, Canada with hormone-like activity causing significant female bias. Significant
changes were observed in fish caught down stream of certain municipalities along the Oldman River correlating with high levels of
vitellogenin expression inmale fish. These observations suggested severe endocrine disruption of gonadal development likely due
to presence of compounds with estrogen-like activity. To investigate the effects of chemicals, we performed controlled laboratory
experiments in which fish in aquaria were exposed to the same concentrations of a selected number of chemicals detected
in the river system, individually and as mixtures. The main focus of the present study was to investigate the mechanisms by
which these compounds disrupt reproduction, using cellular, molecular, transcriptomics and metabolomics approach. The results
demonstrate significant dysregulation of metabolism following exposure to low concentrations of contaminants. Microarray
analysis, identified new cellular response and biological endpoints, and provides information on mechanism-based cell and tissue
response affecting energy cycle and reproduction. In addition, we observed changes in neurostem cell development associated
with hyperactivity following exposure to low environmentally relevant concentration of contaminants. The results demonstrate
that contaminants exert significantly different effects as a mixture, compared to individual compounds in the liver, ovary, testis
and brain. Together with our previous field data, the present results provide a framework for better understanding of ecological
consequences of exposure to contaminants, and resulting reproductive abnormalities seen in fish and other vertebrates.
habibi@ucalgary.caReproductive and developmental impairment by
environmental contaminants
Hamid R Habibi
University of Calgary, Calgary, Alberta, Canada
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009