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Medchem & Toxicology 2018
Page 63
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
A n n u a l C o n g r e s s o n
Medicinal Chemistry,
Pharmacology and toxicology
J u l y 3 0 - 3 1 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
N
itroimidazoles are well recognized as antibacterial agents having a wide range of biological activities such as anticancer,
antifungal, antibacterial, antitubercular etc. Nowadays, various drugs are available which belongs to the nitroimidazole class
such as secnidazole (Flagentyl), metronidazole (Flagyl), ornidazole (Xynor), tinidazole (Fasigyn) and others. Our group has worked
on Pro and Co-drug synthesis of Secnidazole which is an efficient drug in the treatment of protozoal infections along with regio-
specific nitration process of substituted imidazole. A summary of our published work is as under: 1) Regio-specific synthesis
of 1-methyl-4-nitro-1H-imidazole: crystal structure, spectroscopic properties and antimicrobial activities. 2) Esterification of
secnidazole: simple low-cost and less toxic method. 3) Crystal formation and structure determination: a) 2-{[1-(2-methyl-5-
nitro-1H-imidazol-1-yl) propan-2-yloxy] carbonyl} benzoic acid. b)1-(2-Methyl-5-nitro-1H-imidazol-1-yl) propan-2-yl acetate. Key
synthetic process, spectroscopic characterization and antimicrobial activities performed in the above mentioned work will be
presented in this important scientific event.
sajid.jahangir@fuuast.edu.pkSynthetic process, spectroscopic characterization and
antimicrobial activities of nitroimidazoles derivatives
Sajid Jahangir
1
Hafiz Abdullah Shahid
1
Sana Wahid
1
and
Muddasir Hanif
2
1
Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal, Karachi, Pakistan
2
Jiangxi Normal University, Nanchang, China
J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C3-009