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Pain Management 2018
Internal Medicine 2018
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 65
March 26-28, 2018
Vienna, Austria
JOINT EVENT
7
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Internal Medicine and Patient Care
&
6
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Pain Management
Volume 4
Background:
Genetic susceptibility has been proposed in
development and progression of diabetic nephropathy (DN) which
accounts for the majority of chronic renal failure on hemodialysis
among Egyptians. IGF-1 gene polymorphism has been studied in
DN in type 1 diabetes but not yet in type2.
Aim:
The aim of this study is to investigate the association of IGF-
1 gene polymorphism with DN in Egyptians with T2DM.
Methods:
A case control study of 52 T2DM were divided into 26
without DN and 26 with DN, of average age 52.7±6.1. Twenty
five age and sex matched healthy control were selected. We
genotyped two tagging single nucleotide polymorphisms (SNPs)
in IGF-1; rs6214 and rs10860860. Genotypic distribution was
tested for Hardy–Weinberg equilibrium and was evaluated by
using the χ2 tests. Participants were assessed clinically and
laboratory for FBS, HBA1c, serum creatinine, urine albumin, uric
acid and lipid profile.
Results:
The genotype frequency GG of IGF-1 gene SNP rs6214
was associated with the risk of DN (AA: OR=0.98, 95% CI: 0.25 –
3.84, p = 0.97; AG: OR=0.21, 95% CI: 0.05 – 0.79, p = 0.002; GG:
OR= 20.57, 95% CI: 2.25 – 74, p = 0.001). The AA variant genotype
of rs10860860 also associated with the risk of DN (AA: OR=7.37,
95% CI: 1.87 – 30.07, p = 0.001; AT: OR=0.20, 95% CI: 0.05 – 0.78,
p = 0.007; TT: OR= 0.29, 95% CI: 0.01 – 3.59, p = 0.28).
Conclusion:
The variants of rs6214 and rs10860860 in IGF-1
gene entail the risk of DN in Egyptians with T2DM.
Biography
Eman H EL-Adawy has completed Her MD fromMansoura University. She is
a Associate Professor of Internal Medicine and Endocrinology Department
in Spescialized Medical Hospital,Faculty of Medicine, Mansoura City, Egypt.
She published more than 10 papers in reputed journals.
emaneladawy@yahoo.comAssociation of IGF-I gene polymorphism with diabetic
nephropathy in Egyptians with Type 2 diabetes
Eman H EL-Adawy
1
Mohamed A Hegazi
3
, Amal Seleem
2
,
and
Mahmoud E Abdelhamid
4
1
Specialized Medical Hospital - Mansoura University, Egypt
2
Mansoura University Hospital, Egypt
3
Tanta Univeresity, Egypt
Eman H EL-Adawy et al., Int J Anesth Pain Med 2018, Volume 4
DOI: 10.21767/2471-982X-C1-003