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Pain Management 2018
Internal Medicine 2018
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 62
March 26-28, 2018
Vienna, Austria
JOINT EVENT
7
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Internal Medicine and Patient Care
&
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t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Pain Management
Volume 4
Background:
Recently lowering upper limit of normal (ULN)
values of serum alanine aminotransferase (ALT) was suggested.
Aim:
To investigate the prevalence of significant liver disease
among community dwelling elderly (>65 years) in central Israel,
whose ALT level fell in the range between the former and the new
range (‘delta range’).
Patients & Methods:
The database was searched for those
who underwent ≥ 1 ALT measurement (IU/L) in 2002-2012. In
a previous study a new range of ALT has been proposed: men:
15-42, women: 10-26. In this study the prevalence of significant
liver disease in the delta range: men 42-45, women 26-34 was
investigated. APRI, FIB-4 and AAR were applied for evaluating
liver fibrosis. Prevalence of significant liver diseases was set
by Chi-Square tests, mean fibrosis scores were compared using
ANOVA followed by Bonferroni post-hoc test. The receiver
operating characteristic model was used to test the ability of the
scores to predict cirrhosis.
Results:
2022 of 49634 (41% male, mean age of 83±6 years)
were diagnosed with chronic liver disease (CLD) and 366 with
cirrhosis. The two were more prevalent among men (15.3% vs.
4.9% and 4.2% vs. 0.9%, respectively) and women (7.8% vs. 3.3%
and 1.5% vs. 0.4%, respectively) in the delta range compared to
the new ALT range. Mean fibrosis scores of FIB4, APRI and AAR
were significantly increased in the ‘delta range’ compared to the
new ALT range.
Conclusion:
Lowering the current ULN of ALT l may help detecting
significant liver diseases.
Biography
Hemda Weiss she is currently working in Hasharon Hospital, Israel.
avra_ham@017.net.ilLowering the upper limit of normal serum alanine
aminotransferase levels may detect patients with hidden
chronic liver disease in the elderly
Schmilovitz Weiss Hemda
1
, Gingold Belfer Rachel
2
, Issa Nidal
1
, Boltin Doron
2
, Beloos-
esky Yichayaou
2
, Morag Koren Nira
3
, Meyerovitch Joseph
4
and
Weiss Avraham
2
1
Hasharon Hospital - RMC, Israel
2
Beilinson Hospital - RMC, Israel
3
Sackler School of Medicine - Tel Aviv University, Israel
4
Clalit Health - Tel Aviv University, Israel
Schmilovitz Weiss Hemda et al., Int J Anesth Pain Med 2018, Volume 4
DOI: 10.21767/2471-982X-C1-003