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Pain Management 2018
Internal Medicine 2018
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 63
March 26-28, 2018
Vienna, Austria
JOINT EVENT
7
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Internal Medicine and Patient Care
&
6
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Pain Management
Volume 4
Background:
Serum alanine aminotransferase (ALT) levels below
and above normal range has been found to serve as a marker of
liver injury and to predict all-cause mortality. The need to adjust
the normal range by age, gender, or other parameters remains
unclear. The current normal range of serum ALT in Israel is 0-34
IU/L for women and 0-45 IU/L for men.
Aim:
We aimed to test the applicability of the current normal-
range values of ALT in the elderly.
Design:
A retrospective design was used. The study population
consisted of community-dwelling individuals aged ≥65 years who
were tested for serum ALT in 2002 at a large health management
organization and followed until end-December 2012.
Methods:
Data were collected on demographics, laboratory tests,
co-morbidities, and mortality.
Results:
The population included 49,634 subjects (59% women,
mean age 83.2±6.3 years). ALT levels in the range of 16-25 IU/L
were associated with the lowest mortality (HR=1), and values of
<16 IU/L and >25 IU/L (unadjusted) were associated with higher
mortality risk, yielding a U-shaped pattern.
Conclusions:
Very low and very high levels of serum ALT within
current normal range are associated with an increased risk of
death in community-dwelling individuals ≥65 years old.
Biography
Avaharan Weiss is currently working in Beilinson Hospital – RMC, Israel.
avra_ham@017.net.ilHigher and lower levels of serum alanine aminotransferase
within current range in the elderly are associated with all
cause mortality
Hemda Schmilovitz Weiss
1
, Rachel Gingold Belfer
2
, Doron Boltin
2
, Yichayaou
Beloosesky
2
, Joseph Meyerovitch
3
, Ruth Tor
2
, Nidal Issa
1
, Alon Grossman
2
, Nira
Koren Morag
4
and
Avraham Weiss
2
1
Hasharon Hospital - RMC, Israel
2
Beilinson Hospital – RMC, Israel
Hemda Schmilovitz Weiss et al., Int J Anesth Pain Med 2018, Volume 4
DOI: 10.21767/2471-982X-C1-003