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Pain Management 2018
Internal Medicine 2018
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 61
March 26-28, 2018
Vienna, Austria
JOINT EVENT
7
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Internal Medicine and Patient Care
&
6
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Pain Management
Volume 4
Introduction:
Transfusion-dependent iron overload is a
determinant of further complications in patients with conditions
requiring regular blood transfusion; such as thalassemia-β major.
Currently, liver biopsy is used as a gold standard for measuring
liver iron concentration. Magnetic resonance imaging (MRI)
has been proposed as a non-invasive diagnostic method for
measuring liver iron concentration.
Methods:
Literature searching was conducted from Pubmed®,
Embase®, and SCOPUS®. One systematic review and meta-
analysis article was selected from twelve chosen studies. The
article was critically appraised afterwards, using standard criteria
for diagnostic research.
Results:
Twenty eligible studies (cohort and case-control) that
utilized 1.5-T or higher scanner system as the index test, and liver
biopsy as the reference standard were analyzed. In the analysis
of T2 spin echo (SE) and T2* gradient recalled echo (GRE), the
results obtained were positive predictive values (0.81 and 0.74),
negative predictive values (0.83 and 0.88), likelihood ratio positive
(8.85 and 4.86), and likelihood ratio negative (0.10 and 0.05)
respectively. Meta-regression analysis was conducted to explore
heterogeneity between studies.
Discussion:
In comparison to liver biopsy, MRI is proven to be
poorly invasive with the amount of possible sampling errors
similar to the gold standard. Although MRI is not considered
cannot be used for depicting histological stages, it has been
validated as a sensitive and non-invasive diagnostic technique to
evaluate tissue iron content.
Conclusion:
MRI has been proven to be moderately sufficient
for ruling in definite diagnosis of liver iron overload and highly
sufficient for ruling out diagnosis of the same condition.
Biography
Maria Satya Paramitha is a Medical Doctor who has completed her Under-
graduate study in Faculty of Medicine, Universitas Indonesia. She has com-
pleted her Master’s degree by Research in Cancer from Newcastle Universi-
ty Medical School, United Kingdom. In this evidence-based case report, she
was supervised by Dr. Tri Juli Edi Tarigan, SpPD-KEMD from Department of
Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Univer-
sitas Indonesia.
maria.satya85@gmail.comEffectiveness of magnetic resonance imaging in diagnosis of
liver iron overload in Thalassemia-
β
major patients with
regular blood transfusion
Maria Satya Paramitha
and
Tri Juli Edi Tarigan
Faculty of Medicine - Universitas Indonesia, Indonesia
Maria Satya Paramitha et al., Int J Anesth Pain Med 2018, Volume 4
DOI: 10.21767/2471-982X-C1-003