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Infectious Diseases 2018
Journal of Prevention and Infection Control
ISSN: 2471-9668
Page 73
June 07-08, 2018
London, UK
8
th
Edition of International Conference on
Infectious Diseases
T
he success of an organism as a pathogen relies on its ability
to adhere to the surface and remain there under the protective
covering of the extracellularmaterial, which forms the biofilm. The
inclination for bacteria to become surface bound is so ubiquitous
in diverse ecosystem that it suggests a strong survival and
selective advantage for surface dwellers over their free ranging
counterparts. Biofilm formation and persistence has profound
implications for the patient, because microorganisms growing
as biofilm are significantly less susceptible to antibiotics and
host defenses than their planktonic forms. Surface modification
and wettability of polymer treated at variable RF source power is
investigated to study the effect of RF plasma power on extent of
surface modification. Plasma treatment was used to modify the
implant surface to facilitate the adhesion of antimicrobial drug.
Surface topography of the implanted material is one key issue in
medical implant infection as bacterial adhesion is a prerequisite
condition for biofilm formation. RISUG® (reversible inhibition
of sperm under guidance), a copolymer of styrene maleic acid,
is a potent male contraceptive currently undergoing extended
phase III clinical trials in India. In previous studies, RISUG® was
evaluated for its antibacterial properties against both gram-
positive and gram-negative strains of bacteria. The drug has
proven to have effective antimicrobial properties. Therefore the
drug RISUG® is proposed for coating over implanted polymer
surface to overcome initial infection.
vchauhan@amity.eduControlled polymer surface plasma modification for
improved drug adhesion and prevention of medical device
related biofilm infection
Vandana Chauhan
Amity University, India
J Prev Infect Cntrol 2018, Volume 4
DOI: 10.21767/2471-8084-C1-003