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Infectious Diseases 2018
Journal of Prevention and Infection Control
ISSN: 2471-9668
Page 69
June 07-08, 2018
London, UK
8
th
Edition of International Conference on
Infectious Diseases
Background:
Hepatitis B is a major public health problem in
Senegal, a country with high prevalence and a transmission
occurring mainly during infancy. Only, one 6–8 weeks vaccination
campaign was initiated in 2005 and it was part of the expanded
program of immunization.
Aim:
The aim of this study was to determine the prevalence of
HBsAg in children born from HIV-seropositive mothers by using
dried blood specimens.
Methods:
Specimens were collected between July 2007 and
November 2012 from children aged 2–48 weeks in Dakar and
decentralized sites working on HIV mother-to-child transmission
prevention. HBsAg detection was performed using Architect
HBsAg Qualitative II kit (Abbott Diagnostics, Ireland) and for all
reactive samples confirmation was done using Architect HBsAg
Qualitative II Confirmatory kit (Abbott Diagnostics, Ireland).
Results:
Nine hundred thirty samples were collected throughout
the country with 66% out of Dakar, the capital city. The median
age was 20 weeks and 88% of children were less than one year of
age with a sex ratio of 1.27 in favor of boys. HBsAg was detected
in 28 cases giving a global prevalence of 3%. According to age,
HBsAg prevalences were 5.1% for children less than six weeks,
4.1% and 4.6%, respectively, for those aged 12–18 weeks and
18–24 weeks of age. The HIV prevalence was 2.6% with no HIV/
HBV co-infection.
Conclusion:
This study showed a high rate of HBV infection in
children less than 24months, and highlighted the need to promote
birth-dose HBV vaccination as recommended by WHO.
sbgueye@yahoo.frHBV carriage in children born from HIV-seropositive mothers
in Senegal: the need of birth-dose HBV vaccination
Sokhna Bousso Gueye, Halimatou Diop Ndiaye, Gora Lo, Sandrine Mintsa, Ibra-
hima Guindo, Aminata Dia, Amina Sow Sall, Aissatou Gaye-Diallo, Souleymane
Mboup, Cheikh Saad-Bouh Boye
and
Coumba Touré Kane
Hospital Aristide Le Dantec, CHU Dakar, Senegal
Université Cheikh Anta Diop, Senegal
J Prev Infect Cntrol 2018, Volume 4
DOI: 10.21767/2471-8084-C1-003