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Journal of Transmitted Diseases and Immunity
ISSN: 2573-0320 Page 35
Volume 4
May 10-11, 2018
Frankfurt, Germany
Immunology Research 2018
Tissue Science 2018
JOINT EVENT
2 2 n d E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology and
Evolution of Infectious Diseases
&
1 2 t h E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Tissue Engineering and
Regenerative Medicine
Hepatitis C virus (HCV) is a serious infectious disease
that can cause lifelong infection. Infection with chronic
hepatitis C virus (HCV) can lead to autoimmune hepatitis (AIH)
in a minority of patients. Viral infection induces, both (in vivo
and in vitro) tumor necrosis factor (TNF-alpha) production
in hepatocytes, and these findings suggest that TNF-alpha
may have an important role in human liver diseases induced
by viruses, together with the prolactin hormone, which is an
endocrinal hormone that acts like a cytokine involved in immune
response. Our study showed that chronic hepatitis C virus
infection associated with a statistical significant increase in
the antismooth muscle antibody, while no statistical significant
increase in antinuclear antibody were shown in this study. The
study elucidated a statistically non-significant increase in
mean value of prolactin hormone in chronic hepatitis C patients
but a significant increase in tumor necrosis factor-alpha. No
significant correlations were found between prolactin hormone
and tumor necrosis factor-alpha. The study concluded
that chronic hepatitis C associated with an immunological
abnormality mainly represented with antismooth muscle
antibody. Tumor necrosis factor-alpha increased in chronic
hepatitis C virus infection with no significant correlations with
prolactin hormone.
Biography
Prof. Dr. Hadaf Dhafir Al Yaseen was faculty in University of Baghdad in the
Department of Biochemistry, College of Medicine at University of Baghdad.
She finished her Post Doctorate in Clinical Biochemistry at Al-Nahrain Uni-
versity. She is currently the head of the Department of Clinical Biochemistry,
University of Baghdad, Iraq. She actively participated in 43 local conferences
in Iraq and 26 abroad, making a total of 69 conferences attendance and
paper presentation. She also published 85 articles.
Induction of autoimmune antibodies and the immune response
of prolactin direct the management in patients infected with
hepatitis C virus: an Iraqi study
Hadaf Dhafir Al Yaseen
University of Baghdad, Iraq
Hadaf Dhafir Al Yaseen, J Transm Dis Immun 2018, Volume 2
DOI: 10.21767/2573-0320-C2-005