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Journal of Transmitted Diseases and Immunity
ISSN: 2573-0320 Page 32
Volume 4
May 10-11, 2018
Frankfurt, Germany
Immunology Research 2018
Tissue Science 2018
JOINT EVENT
2 2 n d E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology and
Evolution of Infectious Diseases
&
1 2 t h E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Tissue Engineering and
Regenerative Medicine
T ertiary lymphoid organs (TLOs) emerge during non-resolving
peripheral inflammation, but their impact on disease progression
remains unknown. We have found in aged Apoe-/- mice that artery
TLOs (ATLOs) controlled highly territorialized aorta T cell responses.
ATLOs promoted T cell recruitment, primed CD4+ T cells, generated
CD4+ , CD8+ , T regulatory (Treg) effector and central memory cells,
converted naive CD4+ T cells into induced Treg cells, and presented
antigen by an unusual set of dendritic cells and B cells. Meanwhile,
vascular smooth muscle cell lymphotoxin β receptors (VSMC-LT βRs)
protected against atherosclerosis by maintaining structure, cellularity,
and size of ATLOs though VSMC-LTβRs did not affect secondary
lymphoid organs. Atherosclerosis was markedly exacerbated in Apoe-
/- Ltbr-/- and to a similar extent in aged Apoe-/- Ltbrfl/fl, Tagln-cre mice.
These data support the conclusion that the immune system employs
ATLOs to organize aorta T cell homeostasis during aging and that
VSMC-LTβRs participate in atherosclerosis protection via ATLOs.
Biography
Desheng Hu has received his PhD degree in Immunology at the Leibniz In-
stitute for Ageing Research, Jena University, Germany in 2012. After that
he did his Postdoc training in the Institute for Immunology of Helmholtz
Zentrum Munich and in the Institute for Immunology of Ludwig Maximilian
University of Munich. In 2017, he went back to China and established his
own research group in Wuhan Union Hospital, Wuhan, China. His research
focuses on Vascular Immunology. So far, he has published several papers
in high impact factor journals, such as Nature Immunology, Immunity and
Circulation Research.
Artery tertiary lymphoid organs: powerhouses of
atherosclerosis immunity
Desheng Hu
Wuhan Union Hospital, China
Desheng Hu, J Transm Dis Immun 2018, Volume 2
DOI: 10.21767/2573-0320-C2-005