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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
16 th EuroSciCon Conference on
Immunology
M a r c h 1 1 - 1 2 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Immunology 2019
Shih-Hsin Chang et al., J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-009
FHL1 (four and a half LIM domains protein 1), is a cysteine-rich double
Zinc-finger structure protein, highly expresses in skeletal and cardiac
muscles. FHL1 is shown to involve in muscle growth, myoblast dierentiation,
sarcomere formation and structural maintenance. The gene and protein of
FHL1 is associated with several diseases, including Emery–Dreifuss muscular
dystrophy, reducing body myopathy, X-linked myopathy characterized by
postural muscle atrophy, and scapuloperoneal myopathy. Recent study further
shows that the anti-FHL1 autoantibody has a potential pathogenic role in
idiopathic inflammatory myopathies (IIMs) patients. Thus, our study aims to
examine whether the anti-FHL1 autoantibody is associated with IIMs patients in
Taiwan. Anti-FHL1 autoantibodies in plasmas from IIM patients are compared
with healthy controls, as well as disease controls from SLE patients via ELISAs
and immunoblot analyses. We found that the anti-FHL1 autoantibody is shown
to be a novel and muscle-specific autoantibody in Taiwan IIMs patients. It may
coexist with other myositis-specific autoantibody. IIM Patients with anti-FHL1
autoantibody have higher disease severity, especially in dysphagia and muscle
weakness.
Biography
Ju-Pi Li has completed her PhD from National Tsing Hua
UniversityandPostdoctoralstudiesfromImmunologyResearch
Center, National Health Research Institutes in Taiwan. She is an
Assistant Research Fellowof ChinaMedical University Hospital.
She has published about 20 papers in reputed journals.
Dysphagia in idiopathic inflammatory myopathy patients with
anti-FHL1 autoantibody
Shih-Hsin Chang, Ju-Pi Li and Joung-Liang Lan
China Medical University Hospital, Taiwan