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Journal of Clinical Immunology and Allergy

ISSN: 2471-304X

16

th

EuroSciCon Conference on

Immunology

M a r c h 1 1 - 1 2 , 2 0 1 9

Am s t e r d a m , N e t h e r l a n d s

Immunology 2019

Dounya Bounid et al., J Clin Immunol Allergy 2019, Volume:5

DOI: 10.21767/2471-304X-C1-009

T

he thyroid injury is the most frequent organ specific autoimmune disease.

The thyroid gland is the target of two main autoimmune pathologies; Grave

disease (GD) and Hashimoto’s thyroiditis (HT). The autoimmune thyroiditis

(AIT) shares a common immunological marker, which is the presence of

circulating antithyroid antibodies (ATA). The type of these ATA and their

targets define the specificity of each disease. The objective of our study

was to determine the clinical significance of the ATA; thyroid pyroxidase

(TPOAb), thyroid globuline (TGAb) and the TSH-receptor antibodies (TRAb), in

thyroidal and non-thyroidal pathologies. We conducted a cross-sectional and

retrospective study on patients having positive antithyroid antibodies enrolled

at the laboratory of immunology of the University Hospital of Marrakesh during

the period from January 2014 to January 2016. The mean age of our patients

was 38±16 years with a sex-ratio M/F of 0.57. The ATA were associated in

70.9% of cases to hypothyroidism, in 22.15% to hyperthyroidism and in 7 %

of cases to euthyroidism. The hypothyroidism was noted in 83.2% of TPO Ab

positive cases, the hyperthyroidism in 87.2% of TRAb positive cases and the

euthyroidism in 6.4 % of TPOAb positive ones. Thyroiditis were represented

essentially by the HT, noticed in 110 patients (69.6%) and the GD in 37 (23.4%).

ATA were associated to non-thyroidal autoimmune diseases in 29.7% of cases

specially represented by type 1 diabetes, sjogren syndrome, celiac disease,

lupus and the PBC, associated to TPOAb in (10.4% ), (4.8%) ,(4 %), (3.2 %)

and (3.2%). The autoimmune polyendocrinopathy was associated with TRAb

in 7.7 % and TPOAb in 1.6% of cases. These ATA were also associated to

non-thyroidal and non-autoimmune pathologies such as type 2 diabetes and

hypertension which were especially associated to the TPOAb in 5.6 % and 4

% respectively followed by Turner’s syndrome and Crohn’s disease who were

especially associated to TGAb in 6.25 % for each one. The results objectified in

our series suit generally to various series of literature. These results underline

the importance of ATA in clinical practice especially in thyroidal and/or non-

autoimmune pathologies and required a finical interpretation to establish

exactly their real clinical significance and to help for better medical care of

patients.

Biography

Dounya Bounid (MD) has completed his Medical Studies

from School of Medicine, Cadi Ayyad University (Marrakech,

Morocco) and actually Resident in Medical Biology (second

year) in the same university.

dounia.bounid@gmail.com

Clinical significance of antithyroid antibodies

Dounya Bounid

1

, Mourad Chaqraoui

1

, Lahcen Elmoumou

2

and

Brahim Admou

1

1

Cadi ayyad university, Morocco

2

Mohammed VI university hospital, Morocco