27 / 34
Page 64
Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
16
th
EuroSciCon Conference on
Immunology
M a r c h 1 1 - 1 2 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Immunology 2019
Background:
In this study, we investigated the associations of circulating long non-coding RNA (lncRNA) Tmevpg1, transcription
factor T-bet and IFN-γ cytokine relative expressions with severity and occlusion rate of coronary artery disease (CAD) patients.
Methods:
Sixty-four patients suspected of CAD who underwent coronary angiography were consecutively enrolled in this study
and divided into four group CAD 2, 3, 4 patients (N = 48) and CAD1 or controls (N=16) according to coronary angiographic results
and Gensini Score. Blood samples of all participants were collected. Quantitative polymerase chain reaction (qPCR) was used to
measure lncRNA Tmevpg1, transcription factor T-bet and IFNG cytokine expressions in whole blood samples. Serum interferon
gamma (IFN-γ) was evaluated using enzyme-linked immunosorbent assay (ELISA). Gensini Score was used to assess the disease
intensify and occlusion rate of CAD patients.
Results:
LncRNA Tmevpg1 relative expression in CAD patients was upregulated compared with that in controls (P<0.003).
LncRNA Tmevpg1 relative expression was remarkably associated with Gensini Score (P<0.01). Additionally, IFNG expression
and IFN-γ serum levels were significantly increased (P<0.001), while, T-bet expression was not significantly increased. (P=0.06).
Conclusion:
lncRNA Tmevpg1 and INF-γ expression correlated with higher disease severity, elevated inflammation and occlusion
rate in CAD patientS.
Gheitasi.r@yahoo.comLncRNA Tmevpg1 expression and IFN
γ
correlates
with higher disease severity and occlusion
rate according to Gensini Score in patients with
coronary artery disease
Reza Gheitasi and Hamed Manochehry
Hamedan University of Medical Sciences, Iran
J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-009