32 / 34
Page 69
Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
16
th
EuroSciCon Conference on
Immunology
M a r c h 1 1 - 1 2 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Immunology 2019
I
maging cycler® technology (IC®M) is presented as key technology: for the spatial resolution of large protein networks at the
target sites of disease with a discriminatory power for an unlimited number or proteins at a time (dimension unlimited imaging);
for the in situ detection of thousands of distinct multi protein complexes; for the construction of machines able to decode
the mechanism of cell invasion into organs, such as the invasion of autoimmune cells and cancer cells; for the application of
this technology for the efficient finding of therapies selectively blocking these invasions. The example of amyotrophic lateral
sclerosis (ALS) is presented showing that ALS cells were seen by IC® for the first time in the blood, the mechanism of CNS
invasion and pathogenic neuronal axotomy of these cells was completely decoded by IC®, and these ALS cells were efficiently
depleted in blood of patients. This ALS example can be translated for other diseases based on cell invasion. The IC® detection of
somatotopic coding in the innate immune system is key.
walter.schubert@med.ovgu.deThe human toponome project: translating the
spatial protein network code into efficient
therapies
Walter Schubert
Topos Nomos Ltd, Germany
J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-009