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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
16
th
EuroSciCon Conference on
Immunology
M a r c h 1 1 - 1 2 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Immunology 2019
I
nsulin is a key regulator of the glucose metabolism and has an important anabolic function throughout the body. Insulin controls
glucose uptake by many different cells and can modulate various processes where there is need for energy, such as mitogenesis,
gene transcription and autophagy. Under certain conditions, for example, diabetes mellitus, the homeostasis of many tissues
and organs are affected, leading to an increased mortality due to an enhanced susceptibility to infections. This vulnerability to
infection may be partially explained by an inefficient inflammatory response. Several studies in animal models and patients have
demonstrated that diabetic individuals have shown ineffective inflammatory response. This deficiency is reflected by a decrease
in chemotaxis and neutrophils recruitment, altered production of inflammatory mediators such as cytokines and chemokines,
changes in expression of adhesion molecules, the latter two on both: protein synthesis and gene expression. In addition,
macrophages from diabetic animals showed decreased phagocytic and microbicidal activities. In most of the parameters studied
on this animal model, once the insulin therapy is introduced, these parameters can be reverted. To explore the susceptibility to
infections in diabetic patients, the role of insulin in natural immunity against pathogens and inhibiting/reduction of deleterious
effects of inflammation, is the nature of my line of research.
martinsj@usp.brMolecular aspects involved in the modulation of
the inflammatory response by insulin
Joilson O Martins
University of São Paulo, Brazil
J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-009