immunology-2018-posters-abstracts

Immunology 2018

J u l y 0 5 - 0 7 , 2 0 1 8

V i e n n a , A u s t r i a

Page 101

Journal of Clinical Immunology and Allergy

ISSN 2471-304X

1 5

t h

I n t e r n a t i o n a l C o n f e r e n c e o n

Immunology

elminth infection has a profound effect on the immune system. However, the precise natures of the immune changes that

are elicited by human helminth infection have not been sufficiently characterized. Furthermore, the reversibility of these

changes after treatment has not been documented sufficiently. We observed immune profiles of Ethiopian immigrants to Israel

cohort. A longitudinal follow up study involving different group of subjects were conducted. Each group had a baseline data

for series of peripheral blood tests, including: IgE and Eosinophil levels, T-cell populations, T-cell receptors phenotypes, and

cytokines measurement. These tests were all repeated at one year interval. Results were compared between newly-arrived-

Ethiopian-Israelis (NEW-Eth-Il), Long-stayed-Ethiopian-Israelis (OLD-Eth-Il), and Non-immigrant- Israeli controls (NON-Imm-Il).

Out of the 184 individuals 111 were NEW-Eth-Il, who had a high prevalence of helminth infection, the immunological changes were

elivated IgE levels and eosinophil counts, decreased CD4/CD8 ratio, increased proportion of HLA-DR+CD3+, HLA-DR+CD4+ and

HLA-DR+CD8+ cells, decreased proportion of CD45RA+CD4+ (naive) and CD28+CD8+ cells, increased proportion CD45RO+CD4+

(memory) cells, and increased secretion of IL-4 and IL-5 (Th2 type cytokines). In the OLD-Eth-Il, who was all negative for helminth

infection, we did not observe these immune changes and did not differ markedly from that of the NON-Imm-Il controls. Significant

normalizations in the above-mentioned variables were observed in 33 NEW-Eth-Il who have received successful treatment but

not in those who missed the treatment. These findings demonstrate that helminth infection is associated with profound immune

changes, and can be normalized within a short time after helminth eradication

Effects of helminth eradication on the immune system

Weisman Z

, Mahdi J A

2, 3

, Kalinkovich A

1, 4

, Stein M

, Greenberg

4, 5

, Borkow G

, Adlerstein D

1, 2

and Bentwich Z

1, 2

Hotel Dieu de France, Saint-Joseph University Beirut, Lebanon

Insights Allergy Asthma Bronchitis 2018, Volume: 4

DOI: 10.21767/2471-304X-C1-003