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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 96
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
T
he central nervous system (CNS) was originally ruled out as a site of action for scorpion venom, however, neurological
manifestations like convulsion are commonly observed after scorpion stings, especially in young children. Scorpion
venom components stimulate the neuro-endocrino-immunological axes inducing the activation of an inflammatory response.
In this study, we have tested the neuroinflammatory response after an injection of
Androctonus australis hector
(Aah) venom
to 7, 21 postnatal days (pnd) and adult mice by subcutaneous route. Our results showed that Aah venom stimulation lead to a
stronger neuroinflammatory response in immature mice, characterized by an important leukocyte activation and migration from
the circulation to the cerebral tissue. Oxidative stress markers nitric oxide (NO) and malondialdehyde (MDA) were significantly
higher in cerebral tissue of 7 and 21 pnd when compared to adult mice. An increase in reduced glutathione (GSH) and catalase
levels after 1 and 3 h post envenomation was observed in adult and 21 pnd mice in comparison to the control groups. A significant
decrease of antioxidant markers was observed in new borne mice. One hour after envenomation, the immature mice (7 and 21
pnd) revealed alterations in cerebral tissue characterized mainly by hemorrhage and diffuse edema that were more severe than
those observed in adult mice. The results show that Aah venom is able to act on the CNS inducing alterations that could be
involved in scorpion envenomation severity and high mortality especially in children. More studies in this eld are necessary to
develop new therapeutic approach taking into consideration the effect of the scorpion venom on the central nervous system.
ibwassila@gmail.comScorpion venom-induced neuroinflammatory
response: impact on the severity of envenomation
Haddad-Ishak Boushaki Wassila and Laraba-Djebari Fatima
1
The Higher National Veterinary School of Algiers, Algeria
2
USTHB Algiers, Algeria
Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003